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However, existing treatments are limited by ocular surface barriers. This study developed an integrated nanomotor\u2010based eye drop system (HPB@Lip@AB) combining self\u2010propulsion, mitochondrial repair, and multiple antioxidant functions. The nanomotor consists of a hollow Prussian blue (HPB) nanozyme core loaded with ammonia borane (AB) as a molecular hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) precursor, encapsulated within a liposomal shell to form a core\u2013shell structure. In the DED microenvironment, HPB catalyzes the decomposition of hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) to generate oxygen bubbles, propelling the nanomotors to rapidly penetrate the tear film barrier. Following cellular uptake, AB is proposed to generate H\n                    <jats:sub>2<\/jats:sub>\n                    in acidic intracellular environments, potentially acting synergistically with HPB to exert antioxidant, anti\u2010apoptotic, and anti\u2010inflammatory effects. This restores tear secretion, stabilizes the tear film, and repairs the corneal epithelium. H\n                    <jats:sub>2<\/jats:sub>\n                    \u2010related effects were associated with increased aldehyde dehydrogenase 1 family member L2 (ALDH1L2) expression, improved mitochondrial function, and reduced apoptosis and inflammation. Our nanomotor strategy enables efficient DED treatment through combined mechanisms, offering a promising platform for high\u2010penetration ocular drug delivery.\n                  <\/jats:p>","DOI":"10.1002\/advs.77681","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:13:12Z","timestamp":1790140392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease"],"prefix":"10.1002","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Second Affiliated Hospital of Dalian Medical University  Dalian China"},{"name":"Institute of Heart and Vascular Diseases Second Affiliated Hospital of Dalian Medical University  Dalian 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