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However, current approaches for fabricating molds of complex adhesive structures are often constrained by high cost, limited repeatability, and limited ability to fabricate complex 3D geometries. These challenges highlight a critical need for high\u2010strength 3D metal molds that support the scalable manufacturing of mushroom\u2010shaped adhesive architectures. Here, this work introduces a scalable manufacturing route using coordinated double\u2010sided non\u2010simultaneous wet etching. This approach enables precise morphological control and large\u2011area fabrication of mushroom\u2011shaped microstructures in a one\u2010step subtractive process within tens of minutes. By regulating the etching time and mask dimensions, key geometrical parameters, including the necking position and taper angle, can be accurately and reproducibly tuned. The replicated Adhesive structures exhibit high adhesion strength of up to 17.37\u00a0 N cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    under ambient conditions, its performance retention in a vacuum environment reaches 98.26\u00a0%, alongside excellent surface adaptability, reproducibility, and resistance to micro\u2010vibrations. Overall, this work provides an efficient strategy for manufacturing high\u2010performance, 3D bionic adhesives.\n                  <\/jats:p>","DOI":"10.1002\/advs.77709","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:06:45Z","timestamp":1789132005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Scalable Double\u2010Sided Wet Etching Strategy for Large\u2010Area Mushroom\u2010Shaped Bionic Adhesives"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-5436","authenticated-orcid":false,"given":"Keju","family":"Ji","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Bionic Materials and Equipment College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics  Nanjing 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