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Nanomaterials, owing to their tunable physicochemical properties and precise bio\u2010interfacial capabilities, offer innovative platforms not only for delivering general mitochondria\u2010targeted therapy but also for enabling\u2014with promising potential\u2014the emerging paradigms of mitochondrial transfer and transplantation. Nevertheless, a dedicated review systematically summarizing progress in this specific subfield is lacking. To fill this knowledge gap, this review provides a structured synthesis that spans from the biological basis of mitochondrial function and transfer to the broad applications of nanomaterials in mitochondria\u2010targeted therapies, with a dedicated analysis of their roles in mitochondrial targeting, functional modulation, and gene editing. A key topic of this review is the emerging role of nanomaterials in assisting mitochondrial transplantation and transfer. By integrating these insights, this work bridges nanotechnology and mitochondrial medicine, offering a valuable resource for developing organelle\u2010specific therapeutics.<\/jats:p>","DOI":"10.1002\/advs.77713","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondria\u2010Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4477-8001","authenticated-orcid":false,"given":"Yuanyuan","family":"Su","sequence":"first","affiliation":[{"name":"Department of Nephrology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Nephrology University\u2010Town Hospital of Chongqing Medical University  Chongqing 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