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Here, we developed magnetically and metabolically programmed macrophage\u2010based immune microrobots (immunobots) for active solid tumor immunotherapy. The immunobots are constructed by loading bone marrow\u2010derived macrophages (BMDMs) with lipopolysaccharide (LPS)\u2010modified Janus L1\n                    <jats:sub>0<\/jats:sub>\n                    \u2010FePt magnetic microrollers (LMRs), which function both as an external magnetic actuation unit and as biochemical regulators that program macrophages into an anti\u2010tumor phenotype. Optimized LMR loading endows the immunobots with robust propulsion, retention under flow, and enhanced barrier penetration. LMRs drive M1\u2010like polarization through LPS\u2010induced inflammatory activation and FePt\u2010derived labile iron\u2010amplified oxidative stress, leading to altered iron homeostasis, elevated reactive oxygen species (ROS), and enhanced NF\u2010\u03baB signaling. Functionally, immunobots induce ferroptosis\u2010associated immunogenic cell death (ICD) in tumor cells. In vivo, magnetically guided immunobots suppress tumor growth through coordinated remodeling of the tumor immune landscape, including tumor\u2010associated macrophage (TAM) reprogramming, dendritic cell maturation, and enhanced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation. Collectively, this work establishes a magnetically guided and metabolically programmed microrobotic immunotherapy strategy for overcoming the physical, metabolic, and immunological barriers that limit cellular therapy in solid tumors.\n                  <\/jats:p>","DOI":"10.1002\/advs.77760","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetically Guided Macrophage Immunobots Coordinate Iron\u2010Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0394-8209","authenticated-orcid":false,"given":"Xirui","family":"Zeng","sequence":"first","affiliation":[{"name":"Robotics and Autonomous Systems Thrust Systems Hub The Hong Kong University of Science and Technology (Guangzhou) Guangzhou 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