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While E\n                    <jats:sub>2<\/jats:sub>\n                    is indispensable for receptivity, the P\n                    <jats:sub>4<\/jats:sub>\n                    \u2010primed uterus undergoes a transitional phase marked by luminal epithelial remodeling, stromal proliferation, and glandular differentiation, establishing competence for E\n                    <jats:sub>2<\/jats:sub>\n                    action. Precise coordination of P\n                    <jats:sub>4<\/jats:sub>\n                    \u2010progesterone receptor (PR) signaling with estrogenic cues is essential; upstream regulatory mechanisms remain unclear. We identify Salvador homolog 1 (SAV1), a scaffold of the Hippo pathway, as a critical regulator of this temporal coordination. Deletion of\n                    <jats:italic>Sav1<\/jats:italic>\n                    in endometrial cells impaired gland development, disrupted receptivity, and prevented implantation. SAV1 interacts with FKBP52), a progesterone receptor cochaperone, and promotes its mammalian STE20\u2010like kinase 1\/2 (MST1\/2)\u2010dependent phosphorylation, facilitating FK506\u2010binding protein 52 (FKBP52)\u00a0nuclear localization and enhancing PR activation. Loss of SAV1 blunted progesterone signaling, delayed receptive phase, and disrupted competency for implantation. Hormonally induced reactivation after delayed implantation restored receptivity and implantation success in\n                    <jats:italic>Sav1<\/jats:italic>\n                    \u2010deficient mice. These findings identify the MST1\/2\u2010SAV1\u2010FKBP52 axis as an integrator that couples Hippo signaling with steroid receptor activity. By ensuring the temporal precision of progesterone action, SAV1 orchestrates establishment of uterine receptivity and implantation, revealing a previously unrecognized role of noncanonical Hippo signaling in regulating P\n                    <jats:sub>4<\/jats:sub>\n                    \u2010dependent responses that safeguard reproductive success.\n                  <\/jats:p>","DOI":"10.1002\/advs.77761","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:40:09Z","timestamp":1789623609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SAV1 in Cooperation With FKBP52 Participates in Implantation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9135-2418","authenticated-orcid":false,"given":"Yuhan","family":"Shao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Center for Reproductive Medicine 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