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Natural phytochemicals, with their inherent diverse bioactivities, provide a multi\u2010target approach to modulate inflammation and accelerate tissue repair, overcoming the limitations of single\u2010agent interventions. However, their clinical utility is frequently limited by poor physicochemical stability, low bioavailability, and insufficient retention at the wound site. Advanced hydrogel platforms serve as effective delivery systems, capable of encapsulating these potent compounds to ensure localized, sustained, and on\u2010demand release, addressing critical translational barriers. This review examines the wound\u2010healing mechanisms and molecular targets of key phytochemical classes, critically analyzing their physicochemical limitations. We then discuss the rational design principles of phytochemical hydrogel systems, encompassing stimuli\u2010responsive networks, externally triggered release modalities, and 3D\u2010printed scaffolds for precise spatial drug distribution. We also highlight the emerging role of artificial intelligence in accelerating this field, from predicting hydrogel characteristics and screening novel phytochemicals to optimizing formulation strategies. Finally, we propose a strategic translational roadmap, addressing crucial aspects such as botanical standardization, scalable manufacturing, and regulatory pathways, to support the clinical translation of these systems.<\/jats:p>","DOI":"10.1002\/advs.77770","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:13:52Z","timestamp":1789982032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Conventional: A Review of Phytochemical\u2010Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9413-8218","authenticated-orcid":false,"given":"Yitao","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Nursing Zhejiang Chinese Medical University  Hangzhou Zhejiang 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