{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:00:40Z","timestamp":1789984840678,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peri\u2010implant diseases (PID) remain major threats to titanium implant longevity, largely due to insufficient soft tissue integration (STI), which weakens the biological seal and promotes a pathogenic\u2013immunological amplification loop involving early\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    colonization and oxidative stress\u2010induced macrophage dysfunction. Here, we developed a dual\u2010targeting biomimetic nanozyme platform by camouflaging molybdenum diselenide (MoSe\n                    <jats:sub>2<\/jats:sub>\n                    ) nanoflowers with membranes derived from\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010pre\u2010stimulated macrophages (SPMM). This biomimetic design couples\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2013targeting of SPMM with the photothermal activity of MoSe\n                    <jats:sub>2<\/jats:sub>\n                    to achieve targeted contact\u2010enhanced bacterial eradication, while integrating macrophage\u2010targeting of SPMM with reactive oxygen species (ROS)\u2010scavenging activity of MoSe\n                    <jats:sub>2<\/jats:sub>\n                    to alleviate oxidative stress in macrophages. By disrupting the pathogenic\u2013immunological amplification loop, MoSe\n                    <jats:sub>2<\/jats:sub>\n                    @SPMM reshaped a pro\u2010regenerative peri\u2010implant immune microenvironment. In a rat implantation model, near\u2010infrared (NIR)\u2010triggered MoSe\n                    <jats:sub>2<\/jats:sub>\n                    @SPMM suppressed bacterial colonization, promoted macrophage reprogramming, and preserved endothelial and fibroblast functions, thereby enhancing angiogenesis, matrix remodeling, connective tissue attachment, and integrin\u2010mediated tissue\u2013implant adhesion. This biomimetic nanozyme strategy provides a rational framework for coordinating pathogen control and immune regulation to promote peri\u2010implant STI.\n                  <\/jats:p>","DOI":"10.1002\/advs.77771","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:10:23Z","timestamp":1789981823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Targeted Biomimetic MoSe\n                    <sub>2<\/sub>\n                    Nanozymes for Enhancing Peri\u2010Implant Soft Tissue Integration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-8800","authenticated-orcid":false,"given":"Minghao","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2441-4123","authenticated-orcid":false,"given":"Miaomiao","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-4558","authenticated-orcid":false,"given":"Lizhi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Solidification Processing School of Materials Science and Engineering Northwestern Polytechnical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-031X","authenticated-orcid":false,"given":"Hongbo","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.24\u20100154"},{"key":"e_1_2_9_3_1","unstructured":"Grand View Research.Peri\u2010implantitis Market (2025\u20102030): Size Share & Trends Analysis Report by Method Type and Region Updated July 2026. 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