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Excessive inflammatory cytokine release and mitochondrial dysfunction exacerbate tissue damage, contributing to the disease's progression. Mitophagy, a process that eliminates dysfunctional mitochondria, helps regulate reactive oxygen species (ROS) levels and suppress inflammation. However, efficient bacteria clearance remains critical for effective inflammatory modulation. Traditional antibiotics struggle against resistant bacteria, necessitating alternative approaches. ROS\u2010based nanocatalytic therapies, particularly nanozymes, show potential for overcoming ROS generation limitations through external stimuli like ultrasound and magnetic fields. This study designs a sono\u2010magneto\u2010responsive nanozyme (BN@NF) composed of boron nanosheets (BN) and neodymium\u2010doped iron phosphide (Nd:Fe\n                    <jats:sub>2<\/jats:sub>\n                    P, NF), modified to form a Z\u2010scheme heterostructure. Delivered via nebulization, BN@NF generates ROS under combined internal and external stimuli, enabling efficient bacterial killing and biofilm disruption. It also modulates inflammation by inhibiting the NF\u2010\u03baB pathway and promoting mitophagy, reducing pro\u2010inflammatory cytokine release. Additionally, BN@NF enhances macrophage polarization from the pro\u2010inflammatory M1 phenotype to the anti\u2010inflammatory M2 phenotype, aiding tissue repair. This approach provides a promising strategy for treating bacterial pneumonia by combining effective antibacterial action with intelligent anti\u2010inflammatory functions.\n                  <\/jats:p>","DOI":"10.1002\/advs.77785","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:25:41Z","timestamp":1789622741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magneto\u2010Sono\u2010Enhanced Nanozyme Catalysis Drives ROS\u2010Mediated Pathogen Killing and Mitophagy\u2010Linked Inflammation Control in Bacterial Pneumonia"],"prefix":"10.1002","author":[{"given":"Xiaofeng","family":"Luo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering The Affiliated Sanya Central Hospital of Hainan University School of Pharmaceutical Sciences Hainan University  Sanya China"},{"name":"Collaborative Innovation Center 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