{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:02:26Z","timestamp":1789624946481,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402416"],"award-info":[{"award-number":["32402416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751044"],"award-info":[{"award-number":["2024M751044"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFD1400700"],"award-info":[{"award-number":["2024YFD1400700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The transcription factor FgSR functions as a central regulator of ergosterol biosynthesis and 14\u03b1\u2010demethylation inhibitor (DMI) sensitivity in\n                    <jats:italic>Fusarium graminearum<\/jats:italic>\n                    , with its orthologous proteins being evolutionarily conserved within Sordariomycetes and Leotiomycetes fungi. In this study, we demonstrate that sterol regulators (SRs) differentially modulate DMI sensitivity across these fungal classes through divergent strategies involving key metabolic genes. In\n                    <jats:italic>Magnaporthe oryzae<\/jats:italic>\n                    , MoSR regulates DMI sensitivity through two distinct mechanisms: it directly modulates the transcription of ergosterol biosynthesis genes\n                    <jats:italic>MoCYP51A<\/jats:italic>\n                    and\n                    <jats:italic>MoCYP51B<\/jats:italic>\n                    , and binds to the DRE (DMI\u2010responsive element) motif to regulate\n                    <jats:italic>MoDde1<\/jats:italic>\n                    (\n                    <jats:italic>Magnaporthe oryzae<\/jats:italic>\n                    DMI detoxification enzyme 1), a gene encoding a cytochrome P450 monooxygenase involved in detoxification. Evolutionary analysis indicates that MoDde1 functions as a Sordariomycetes\u2010specific detoxification factor, capable of enzymatically degrading DMIs. Based on these findings, we developed a small\u2010molecule D1 targeting MoDde1 and engineered rice lines with reduced\n                    <jats:italic>MoDde1<\/jats:italic>\n                    expression using host\u2010induced gene silencing (HIGS). Both approaches successfully suppressed the enzymatic activity and expression of MoDde1, respectively, demonstrating a promising sustainable strategy for controlling rice blast disease, particularly in conjunction with DMI fungicides.\n                  <\/jats:p>","DOI":"10.1002\/advs.77796","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:13:24Z","timestamp":1789622004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The MoSR\u2010MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-165X","authenticated-orcid":false,"given":"Fan\u2010Zhu","family":"Meng","sequence":"first","affiliation":[{"name":"The Hubei Key Lab of Plant Pathology, College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Kai","family":"Wei","sequence":"additional","affiliation":[{"name":"The Hubei Key Lab of Plant Pathology, College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Yao","family":"Wu","sequence":"additional","affiliation":[{"name":"The Hubei Key Lab of Plant Pathology, College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Zheng","family":"Cai","sequence":"additional","affiliation":[{"name":"The Hubei Key Lab of Plant Pathology, College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-3590","authenticated-orcid":false,"given":"Yu\u2010Fu","family":"Wang","sequence":"additional","affiliation":[{"name":"Yazhouwan National Laboratory  Sanya China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8940-8873","authenticated-orcid":false,"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Hubei Key Lab of Plant Pathology, College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1867-1382","authenticated-orcid":false,"given":"Shuai","family":"Meng","sequence":"additional","affiliation":[{"name":"National Joint Local Engineering Laboratory For High\u2010Efficient Preparation of Biopesticide, College of Forestry and Biotechnology Zhejiang Agriculture and Forestry University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Fen","family":"Yin","sequence":"additional","affiliation":[{"name":"The Experimental Teaching Center of Crop Science, College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-1920","authenticated-orcid":false,"given":"Guido","family":"Schnabel","sequence":"additional","affiliation":[{"name":"Department of Plant and Environmental Sciences Clemson University  Clemson South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-3979","authenticated-orcid":false,"given":"Wei\u2010Xiao","family":"Yin","sequence":"additional","affiliation":[{"name":"The Hubei Key Lab of Plant Pathology, College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-9898","authenticated-orcid":false,"given":"Chao\u2010Xi","family":"Luo","sequence":"additional","affiliation":[{"name":"The Hubei Key Lab of Plant Pathology, College of Plant Science and Technology Huazhong Agricultural University  Wuhan China"},{"name":"National Joint Local Engineering Laboratory For High\u2010Efficient Preparation of Biopesticide, College of Forestry and Biotechnology Zhejiang Agriculture and Forestry University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature10947","article-title":"Emerging Fungal Threats to Animal, Plant and Ecosystem Health","volume":"484","author":"Fisher M. 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