{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:00:33Z","timestamp":1790780433434,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1001600"],"award-info":[{"award-number":["2023YFF1001600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Food allergies affect over 8% of children globally, with a 3.5\u2010fold increase in incidence in the past two decades. However, disease\u2010modifying therapies remain limited due to incomplete understanding of the underlying metabolic mechanisms. Thus, in this study, we aimed to demonstrate if spermidine\/spermine N\n                    <jats:sup>1<\/jats:sup>\n                    \u2010acetyltransferase (SAT1)\u2010mediated spermidine depletion drives food allergy pathogenesis through a previously unrecognized metabolic\u2010immunological axis. Using a peanut allergy mouse model complemented by additional food allergen systems, we show that spermidine levels are significantly reduced during allergic responses, while exogenous supplementation attenuates disease severity. Moreover, SAT1 is markedly upregulated in allergic tissues, particularly in mast cells, where it promotes degranulation by suppressing autophagy. Mechanistically, SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit autophagy\u2010related genes, including\n                    <jats:italic>Atg5<\/jats:italic>\n                    and\n                    <jats:italic>Atg7<\/jats:italic>\n                    . Genetic or pharmacological targeting of the SAT1\u2010Cdk19os\u2010autophagy axis through SAT1\/Cdk19os knockdown, spermidine supplementation, or autophagy induction effectively ameliorates allergic inflammation and reduces mast cell activation. These findings reveal that metabolic reprogramming actively drives food allergy development and identify tractable therapeutic targets and accessible dietary interventions in murine models. These results establish a conceptual framework for understanding the metabolic\u2010immunological basis of food allergy and open new avenues for translational investigation into this increasingly prevalent condition.\n                  <\/jats:p>","DOI":"10.1002\/advs.77798","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SAT1\u2010Induced Spermidine Depletion Potentiates Food Allergy"],"prefix":"10.1002","author":[{"given":"Manman","family":"Liu","sequence":"first","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of China"},{"name":"Key Laboratory of Food Nutrition and Health Evaluation Technology State Administration for Market Regulation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of China"},{"name":"Key Laboratory of Food Nutrition and Health Evaluation Technology State Administration for Market Regulation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-7843","authenticated-orcid":false,"given":"Junjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Agri\u2010food Processing and Nutrition Beijing Academy of Agriculture and Forestry Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of China"},{"name":"Key Laboratory of Food Nutrition and Health Evaluation Technology State Administration for Market Regulation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-4541","authenticated-orcid":false,"given":"Shiwen","family":"Han","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of China"},{"name":"Key Laboratory of Food Nutrition and Health Evaluation Technology State Administration for Market Regulation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2559-8350","authenticated-orcid":false,"given":"Qianwei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of China"},{"name":"Key Laboratory of Food Nutrition and Health Evaluation Technology State Administration for Market Regulation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7276-2075","authenticated-orcid":false,"given":"Lingyu","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of China"},{"name":"Key Laboratory of Food Nutrition and Health Evaluation Technology State Administration for Market Regulation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5899-8075","authenticated-orcid":false,"given":"Jinfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1632-5729","authenticated-orcid":false,"given":"Huilian","family":"Che","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing People's Republic of China"},{"name":"Key Laboratory of Food Nutrition and Health Evaluation Technology State Administration for Market Regulation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010090122\u2010043501"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14666"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882\u2010020\u20100898\u20107"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312382"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.10.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010021\u201000622\u2010y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001954\u20106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.70"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010022\u201000473\u20102"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4222"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj3510"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201016\u20103462"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjad058"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan278"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.731661"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010018\u20100050\u20103"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2021.11.1018"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010090122\u2010043501"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.111"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101354"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.007"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115926"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.02.011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.04.007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010018\u20100050\u20103"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13080690"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010019\u20100295\u20108"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1078"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.215"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1975"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201008167"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0523"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.130"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.031"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.05.021"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3771"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010025\u201002355\u20109"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.11.918"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7085271"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812856"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15658"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.001"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010022\u201000473\u20102"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.446"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201060235\u20100"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77798","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:39:33Z","timestamp":1790779173000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":46,"alternative-id":["10.1002\/advs.77798"],"URL":"https:\/\/doi.org\/10.1002\/advs.77798","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77798"}}