{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:59:56Z","timestamp":1790780396196,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202208320061"],"award-info":[{"award-number":["202208320061"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275093"],"award-info":[{"award-number":["22275093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275094"],"award-info":[{"award-number":["22275094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Efficient and safe intracellular delivery of macromolecules, like nucleic acids, remains a major challenge in ex vivo cell engineering. While photoporation is a highly attractive method for cytosolic delivery of (macro)molecules, photosensitizers remaining in the photoporated cells may pose safety concerns, especially when the cells are engineered for therapeutic use. In this study we introduce the concept of \u201cdetachable photosensitizers\u201d using gold nanoparticles (AuNPs) as photosensitizer. We demonstrate that phenylboronic acid (PBA)\u2010functionalized AuNPs can be anchored to membranes of HeLa cells and Jurkat cells, thereby enabling the efficient intracellular delivery of dextrans and mRNA upon pulsed laser irradiation (photoporation). Subsequently, the PBA\u2010AuNPs can be detached from the cells \u201con\u2010demand\u201d by adding ATP to the cell medium, as\n                    <jats:italic>cis\u2010<\/jats:italic>\n                    diol groups in ATP displace the boronate ester bonds between the PBA\u2010AuNPs and cell\u2010surface. ICP\u2010MS analysis demonstrated efficient detachment, with the average cell\u2010associated gold mass per viable cell falling below the theoretical mass of a single intact 80 nm AuNP. This \u201cattach\u2010and\u2010detach\u201d strategy offers a robust and effective approach to addressing safety concerns associated with the use of plasmonic nanomaterials as sensitizers for photoporation, and holds significant potential for the safe manufacturing of engineered cells in the context of cell therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.77816","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0002-390X","authenticated-orcid":false,"given":"Tao","family":"Lu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Development and Utilization of Forest Food Resources Joint Laboratory of Advanced Biomedical Materials (NFU\u2010UGent) Jiangsu Co\u2010Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University  Nanjing China"},{"name":"Laboratory of General Biochemistry and Physical Pharmacy Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5345-3703","authenticated-orcid":false,"given":"Mina","family":"Nikoli\u0107","sequence":"additional","affiliation":[{"name":"Atomic and Mass Spectrometry \u2013 A&amp;MS research group Department of Chemistry Faculty of Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihao","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy Faculty of Pharmaceutical Sciences Ghent University  Ghent 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and Mass Spectrometry \u2013 A&amp;MS research group Department of Chemistry Faculty of Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Xie","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-0674","authenticated-orcid":false,"given":"Florian","family":"Vanlauwe","sequence":"additional","affiliation":[{"name":"Tissue Regeneration and Organ Printing (TROP) Research Center Department of Human Structure and Repair Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Blondeel","sequence":"additional","affiliation":[{"name":"Tissue Regeneration and Organ Printing (TROP) Research Center Department of Human Structure and Repair Ghent 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of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-0545","authenticated-orcid":false,"given":"Chaobo","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Development and Utilization of Forest Food Resources Joint Laboratory of Advanced Biomedical Materials (NFU\u2010UGent) Jiangsu Co\u2010Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-3853","authenticated-orcid":false,"given":"Frank","family":"Vanhaecke","sequence":"additional","affiliation":[{"name":"Atomic and Mass Spectrometry \u2013 A&amp;MS research group Department of Chemistry Faculty of Sciences Ghent University  Ghent 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Forest Food Resources Joint Laboratory of Advanced Biomedical Materials (NFU\u2010UGent) Jiangsu Co\u2010Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University  Nanjing China"},{"name":"Laboratory of General Biochemistry and Physical Pharmacy Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"7409","DOI":"10.1021\/acs.chemrev.7b00678","article-title":"Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts","volume":"118","author":"Stewart M. 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