{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:00:11Z","timestamp":1790791211346,"version":"4.1.0"},"reference-count":91,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM127045"],"award-info":[{"award-number":["R35GM127045"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015311","name":"Novartis Institutes for BioMedical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015311","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemical\u2010induced proximity, particularly via molecular glues, represents a rapidly advancing therapeutic paradigm. Expanding the scope of proximity\u2010based therapeutics requires generalizable discovery platforms that can be easily tailored to diverse presenter proteins. Here, we report a versatile DNA\u2010encoded library (DEL) strategy designed to identify highly cooperative chemical inducers of proximity (CIPs) for multiple presenter proteins. By leveraging a novel precursor library constructed via on\u2010DNA strained allene cycloadditions, we generated three distinct CIP\u2010DELs biased toward Cereblon (CRBN), VHL, and FKBP12. Screening the CRBN\u2010focused library with BRD9 identified\n                    <jats:bold>B67b<\/jats:bold>\n                    , a novel compound that mediates ternary complex formation between CRBN and BRD9 with nanomolar potency and strong molecular glue\u2010like cooperativity (\u03b1 &gt;300).\n                    <jats:bold>B67b<\/jats:bold>\n                    engages BRD9 in a CRBN\u2010dependent manner, a characteristic of classical molecular glues, and its high cooperativity is driven by the synergistic contribution of all its structural and stereochemical components. This work establishes a scalable, generalizable framework for repurposing generic DELs into presenter\u2010specific screening tools, offering a powerful approach to accelerate the discovery of CIP therapeutics for a broad range of targets.\n                  <\/jats:p>","DOI":"10.1002\/advs.77819","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Versatile DNA\u2010Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9139-4328","authenticated-orcid":false,"given":"Bingqi","family":"Tong","sequence":"first","affiliation":[{"name":"Global Discovery Chemistry Novartis Biomedical Research  Cambridge Massachusetts USA"},{"name":"Chemical Biology and Therapeutics Science Broad 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