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Single\u2010cell transcriptomic reanalysis and clinical AF specimens identified ferroptosis\u2010associated redox imbalance as a prominent feature of advanced degeneration. Here, we developed an acid\u2010responsive nanobot\u2010integrated core\u2010shell microneedle system for staged annulus fibrosus repair. The shell layer released TA@MgO\n                    <jats:sub>2<\/jats:sub>\n                    metal\u2010phenolic nanobots that consumed pathological H\n                    <jats:sup>+<\/jats:sup>\n                    , generated O\n                    <jats:sub>2<\/jats:sub>\n                    , and provided NIR\u2010amplified redox buffering, thereby normalizing the early degenerative microenvironment. The core layer enabled sustained quercetin release to reinforce anti\u2010ferroptotic and matrix\u2010preserving effects. Mechanistically, TMH\/QG+NIR suppressed ferroptosis in AF cells by epigenetically silencing ATF3 through DNMT3A\u2010dependent promoter methylation, thereby relieving ATF3\u2010mediated repression of SLC7A11 and restoring GPX4\u2010dependent antioxidant defense. In a puncture\u2010induced degeneration model, this system alleviated ferroptotic injury, improved AF integrity, preserved disc height and enhanced biomechanical resilience. These findings identify the DNMT3A\u2010ATF3\u2010SLC7A11 axis as a therapeutically tractable ferroptosis\u2010regulatory pathway and establish a staged microenvironment\u2010reprogramming strategy for AF repair.\n                  <\/jats:p>","DOI":"10.1002\/advs.77829","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acid\u2010Responsive Nanobot\u2010Integrated Core\u2010Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7654-8533","authenticated-orcid":false,"given":"Lu","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Orthopedics Xinqiao Hospital Army Medical University  Chongqing China"},{"name":"Chongqing Municipal 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Orthopedics Xinqiao Hospital Army Medical University  Chongqing China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Precise Orthopedics Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-9105","authenticated-orcid":false,"given":"Changqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Xinqiao Hospital Army Medical University  Chongqing China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Precise Orthopedics Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-0766","authenticated-orcid":false,"given":"Yanqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Xinqiao Hospital Army Medical University  Chongqing China"},{"name":"Chongqing Municipal Health Commission Key Laboratory of Precise Orthopedics Chongqing 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