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Herein, a hierarchical nanoplatform (CM\/LDH) is fabricated by immobilizing Ce\u2010MOF nanozyme onto CaAl\u2010LDH substrate for synergistic bone remediation. As an alkaline and bioactive support, CaAl\u2010LDH improves peri\u2010defect microenvironment acidification to preserve the redox catalytic activity of loaded Ce\u2010MOF, accompanied with sustained Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    release to support BMSC viability and osteogenic differentiation. The immobilized Ce\u2010MOF component eliminates excessive ROS via reversible Ce\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \/Ce\n                    <jats:sup>4<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    cycling, further alleviating inflammatory polarization of macrophages and cutting off pathological cell crosstalk. Benefiting from mutual complementary functions, CM\/LDH synchronously rectifies oxidative\u2010acidic microenvironment and rebalances osteogenic\u2010osteoclastic turnover, overcoming inherent drawbacks of single\u2010target interventions. This synergistic nanosystem provides a potential biomaterial option for diabetic craniofacial bone regeneration.\n                  <\/jats:p>","DOI":"10.1002\/advs.77841","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hierarchical Nanoplatform Integrating Oxidative\u2013Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3928-1598","authenticated-orcid":false,"given":"Xu","family":"Chen","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Oral Diseases Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering The Affiliated Stomatological 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