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Here, we developed a liquid\u2010responsive shape\u2010memory, core\u2013shell nanofiber\u2010reinforced, directionally porous scaffold (QCG\u20102%F\/KGN) for endogenous cartilage regeneration. KGN\u2010loaded SF\/PCL\u2013PVA core\u2013shell nanofibers were fabricated by coaxial electrospinning, fragmented, incorporated into a quaternized chitosan\/gelatin matrix, and assembled by directional freeze\u2010casting. The aligned microchannels provided a structurally permissive route for cell infiltration and distribution, while the nanofiber network enhanced pore\u2010wall roughness, structural stability, water retention, and hydration\u2010triggered shape recovery. The core\u2013shell fibers also enabled sustained KGN release over 30\u2010day period. In vitro, QCG\u20102%F\/KGN maintained high cell viability and promoted BMSC migratory activity, spreading, chondrogenic differentiation, and cartilage\u2010matrix deposition. In a rat full\u2010thickness cartilage\u2010defect model, the scaffold conformally filled the defect and enhanced hyaline cartilage like regeneration, accompanied by increased SOX9, COL2A1, and ACAN and decreased COL1A1 and MMP13. Transcriptomic analysis further indicated enrichment of cartilage\u2010anabolic programs and attenuation of inflammatory signaling. These findings support a sequential regenerative strategy integrating shape\u2010adaptive implantation, a microarchitecture favorable for endogenous cell infiltration, and sustained chondrogenic induction.<\/jats:p>","DOI":"10.1002\/advs.77845","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liquid\u2010Responsive Shape\u2010Memory Nanofiber\u2010Reinforced Scaffolds for Cartilage Repair"],"prefix":"10.1002","author":[{"given":"Jiyang","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Spine Surgery Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Hunan Digital Spine Research Institute Department of Science and Technology of Hunan Province  Changsha 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