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Antimicrobial blue light (aBL, \u223c405\u2010450\u00a0nm) generates intracellular reactive oxygen species through excitation of endogenous chromophores, while nitric oxide (NO) induces complementary nitrosative and oxidative damage.\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitrosothiols (RSNOs) provide a platform for visible\u2010light\u2010triggered NO release. Here, a synergistic antimicrobial strategy combining aBL with RSNO coatings was developed to simultaneously generate reactive oxygen and nitrogen species and evaluated against bacterial and fungal pathogens. Four RSNO donors (\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitroso\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylpenicillamine (SNAP),\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitrosoglutathione (GSNO),\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitroso\u20101\u2010adamantanethiol (SNAT), and\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitrosotriphenylmethanethiol (Ph\n                    <jats:sub>3<\/jats:sub>\n                    \u2010CSNO)) were incorporated into catheter insert coatings and exhibited distinct, wavelength\u2010dependent NO\u2010release profiles, with aBL enhancing NO release for all formulations. SNAT showed the greatest photochemical response, with a 235% increase in steady\u2010state NO flux under irradiation. The combined generation of reactive species produced potent broad\u2010spectrum antimicrobial activity against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , MRSA,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , achieving &gt;4\u2010log reductions in microbial viability with all RSNO\u2010coated inserts under aBL after 24\u00a0h. In vivo, SNAT\u2010coated inserts significantly reduced\n                    <jats:italic>S. aureus<\/jats:italic>\n                    colonization in a rabbit infection model, achieving up to a 2.35\u2010log reduction in bacterial burden, demonstrating that light\u2010triggered NO delivery combined with aBL provides an antibiotic\u2010independent strategy for preventing device\u2010associated infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.77846","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Smartphone\u2010Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9611-7395","authenticated-orcid":false,"given":"Alexander","family":"Bruckmann","sequence":"first","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7594-8387","authenticated-orcid":false,"given":"Adam Brooks","family":"Goodman","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5779-2074","authenticated-orcid":false,"given":"Myddelton C.","family":"Parker","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  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of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-7374","authenticated-orcid":false,"given":"Hitesh","family":"Handa","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia USA"},{"name":"Department of Pharmaceutical and Biomedical Sciences College of Pharmacy University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-5448","authenticated-orcid":false,"given":"Elizabeth J.","family":"Brisbois","sequence":"additional","affiliation":[{"name":"School of Chemical Materials and Biomedical Engineering College of Engineering University of Georgia  Athens Georgia 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