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The nanoparticles displayed a uniform size of 250\u2013300\u00a0nm, high encapsulation efficiency, and favorable colloidal stability. Their release behavior was accelerated under acidic and ROS\u2010enriched conditions, supporting lesion\u2010responsive silymarin delivery. Compared with free silymarin, Sil@PBACS Nps (Nps) exhibited stronger antioxidant activity, with DPPH and ABTS scavenging rates of 92.31% and 73.78%, respectively, together with moderate antibacterial effects against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    . The formulation showed good biocompatibility, with hemolysis below 5% and cell viability above 80% in AML\u201012 and HepG2 cells. In a canine hepatectomy model, oral Sil@PBACS Nps reshaped gut microbial composition and altered fecal metabolites associated with sphingolipid metabolism and the pentose phosphate pathway, while hepatic proteomics indicated pathway\u2010level changes related to oxidative phosphorylation and fatty acid biosynthesis. Further validation of the targeted proteins in the mouse model confirmed the involvement of intestinal barrier\u2010related responses in the mouse model and hepatic inflammatory, bile acid, antioxidant, lipid\u2010metabolic, and apoptosis\/recovery\u2010associated pathways in both murine liver tissues. These results suggest that Sil@PBACS Nps facilitate post\u2010hepatectomy liver recovery by integrating stimuli\u2010responsive delivery, redox regulation, and gut\u2013liver axis\u2010associated hepatic protection.\n                  <\/jats:p>","DOI":"10.1002\/advs.77847","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ROS\/pH\u2010Responsive Phenylboronic Acid\u2013Chitosan Nanoparticles Improve Silymarin\u2010Mediated Hepatoprotection After Hepatectomy With Gut\u2010Liver Axis\u2010Associated Responses"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3597-9055","authenticated-orcid":false,"given":"Jinjin","family":"Tong","sequence":"first","affiliation":[{"name":"Animal Science and Technology College Beijing University of Agriculture  Beijing People's Republic of 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