{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:10:52Z","timestamp":1790784652586,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nitric oxide (NO)\u2010based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a multistimuli\u2010activated Janus nanomotor was developed to interconnect nonenzymatic and enzymatic NO\u2010generation pathways, enabling in situ self\u2010cascading NO production. The nanomotor comprises an AuPt\n                    <jats:sub>3<\/jats:sub>\n                    Cu nanozyme asymmetrically coated with a disulfide\u2010bridged mesoporous silica shell (2sMSN) loaded with L\u2010arginine, allowing autonomous propulsion under O\n                    <jats:sub>2<\/jats:sub>\n                    , NO, and NIR irradiation to achieve deep tumor penetration. Upon cellular internalization, the asymmetric architecture enables concurrent AuPt\n                    <jats:sub>3<\/jats:sub>\n                    Cu\u2010catalyzed oxidation of glucose to H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and GSH\u2010responsive degradation of 2sMSN to release L\u2010arginine, thereby coupling nonenzymatic NO generation through H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010mediated L\u2010arginine oxidation. Subsequently, the resulting nitrosative stress suppresses glycolysis and drives compensatory pentose phosphate pathway activation, thereby increasing cofactor availability and enhancing nitric oxide synthase\u2013dependent NO production. This self\u2010amplifying NO loop further amplifies mild photothermal therapy by inducing HSP90 downregulation, thereby triggering immunogenic cell death and achieving effective melanoma clearance. Overall, this Janus nanomotor presents an \u201casymmetric structure\u2010driven functional synergy\u201d strategy for controllable, sustained, and uniform NO generation, offering a distinctive paradigm to overcome the intrinsic penetration and sustainability limitations of gas\u2010based therapeutic modalities.\n                  <\/jats:p>","DOI":"10.1002\/advs.77848","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetric Structure\u2010Driven Functional Synergy: A Multistimuli\u2010Activated Janus Nanomotor for Self\u2010Amplifying NO Cascade Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9900-8804","authenticated-orcid":false,"given":"Chengcheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Colorectal and Anal Surgery 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