{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:56:39Z","timestamp":1790794599937,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The temporal lobes are key hubs for memory and cognition. Although 40\u00a0Hz transcranial alternating current stimulation (tACS) has shown potential cognitive benefits, evidence for accelerated bilateral temporal stimulation remains limited. This study aims to evaluate its cognitive and neural effects. In this randomized, double\u2010blind, controlled trial, 100 Alzheimer's disease (AD) patients were randomized 1:1 to active or sham 40\u00a0Hz tACS over the bilateral temporal. Cognitive outcomes at three time points were analyzed using mixed repeated\u2010measures analysis of variance (ANOVA). Resting\u2010state functional near\u2010infrared spectroscopy (fNIRS) data from baseline and Week 4 were analyzed using ANOVA, followed by network\u2010based statistics with family\u2010wise error (FWE) correction. Eighty\u2010five participants completed the trial. Significant Group \u00d7 Time interactions were observed for Alzheimer's Disease Assessment Scale\u2010Cognitive Subscale (ADAS\u2010Cog) total (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.010), memory (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.007), and praxis (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002), but not for the Mini\u2010Mental State Examination (MMSE) (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.075). The fNIRS analysis revealed a functional network primarily involving the frontal and parietal regions, comprising 38 connections and 18 nodes (\n                    <jats:italic>\n                      p\n                      <jats:sub>FWE<\/jats:sub>\n                    <\/jats:italic>\n                    = 0.010). Active\u2010group connectivity changes were associated with ADAS\u2010Cog total, language, praxis, and MMSE variations, but not in the sham group. Accelerated bilateral temporal 40\u00a0Hz tACS improved cognition and modulated frontotemporoparietal connectivity. Larger multicenter studies with biomarkers are warranted.\n                  <\/jats:p>","DOI":"10.1002\/advs.77851","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal\u2010Targeted Accelerated 40\u00a0Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5038-0599","authenticated-orcid":false,"given":"Rong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Psychiatry Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital)  Ningbo Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-7625","authenticated-orcid":false,"given":"Xingxing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital)  Ningbo Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjun","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital)  Ningbo Zhejiang People's Republic of 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Psychiatry Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital)  Ningbo Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital)  Ningbo Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Health Science Center Ningbo University  Ningbo People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital)  Ningbo Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Second People's Hospital of Lishui  Lishui Zhejiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9326-4242","authenticated-orcid":false,"given":"Dongsheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders Affiliated Kangning Hospital 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