{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:56:32Z","timestamp":1790535392576,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22571284"],"award-info":[{"award-number":["22571284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22531008"],"award-info":[{"award-number":["22531008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22101265"],"award-info":[{"award-number":["22101265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The low toxicity and cost\u2010effectiveness of light main\u2010group metal photochemical systems render them highly suitable for drug development, while the redox inertness of light main\u2010group metals significantly hinders this goal. Herein, through the in situ assembly of readily available lithium nitrate, methoxyacetic acid, and aniline substrates, an unprecedented, mild lithium\u2010based photochemical system capable of producing valuable nitro radicals is established. This system enables selective C(sp\n                    <jats:sup>2<\/jats:sup>\n                    )\u2013H (di\u2010)nitration of anilines for synthesizing nitro\u2010aromatic compounds as potential antitumor candidates. Further, replacing lithium nitrate with magnesium nitrate makes the reaction conditions milder, allowing lower\u2010energy green\u2010light irradiation for the (di\u2010)nitration. The two main\u2010group metal photochemical systems also enable direct late\u2010stage functionalization of complex drug molecules, eliminating the risk of transition metal residue and drastically simplifying the workup procedures of pharmaceutical manufacturing processes.\n                  <\/jats:p>","DOI":"10.1002\/advs.77873","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:45:26Z","timestamp":1790325926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unlocking Li\/Mg\u2010Based Photochemical Nitration Platforms for Anticancer Drug Discovery"],"prefix":"10.1002","author":[{"given":"Qian","family":"Wan","sequence":"first","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory the First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luchuan","family":"Ou","sequence":"additional","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology School of Basic Medical Sciences Zhengzhou University  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-0020","authenticated-orcid":false,"given":"Yu","family":"Lan","sequence":"additional","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"},{"name":"State Key Laboratory of Antiviral Drugs Henan Normal University  Xinxiang Henan People's Republic of China"},{"name":"School of Chemistry and Chemical Engineering Chongqing Key Laboratory of Chemical Theory and Mechanism Chongqing University  Chongqing People's Republic of China"},{"name":"Key Laboratory of Special Functional Molecular Materials (Zhengzhou University) Ministry of Education  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-0260","authenticated-orcid":false,"given":"Shihan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Sciences Henan University  Kaifeng Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-8203","authenticated-orcid":false,"given":"Yan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology School of Basic Medical Sciences Zhengzhou University  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Jun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"},{"name":"State Key Laboratory of Antiviral Drugs Henan Normal University  Xinxiang Henan People's Republic of China"},{"name":"Key Laboratory of Special Functional Molecular Materials (Zhengzhou University) Ministry of Education  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0798-3444","authenticated-orcid":false,"given":"Zhigang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory the First Affiliated Hospital of Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbin","family":"Niu","sequence":"additional","affiliation":[{"name":"College of Chemistry State Key Laboratory of Antiviral Drugs and Pingyuan Laboratory Zhengzhou University  Zhengzhou Henan People's Republic of China"},{"name":"State Key Laboratory of Antiviral Drugs Henan Normal University  Xinxiang Henan People's Republic of China"},{"name":"Key Laboratory of Special Functional Molecular Materials (Zhengzhou University) Ministry of Education  Zhengzhou Henan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214744"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010016\u20109471\u20106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md22060253"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00833"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201008\u2010097774\u20104.00338\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28155921"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed031p446"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1134\/S001670290601006X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2026.116492"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202507060"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202524691"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202402885"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202418367"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10333"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6c04805"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5c00194"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006407\u20108"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202501753"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6c00395"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal15020135"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202500396"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC05048C"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC00692E"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CC05586E"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5GC05996H"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201701242"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c06651"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020882\u2010x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010025\u201001438\u2010y"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05631"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c03755"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202315046"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2025.155819"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c15802"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03154"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01984"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO01003H"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac199264091311"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00696"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2025.102702"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC04038D"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050507\u20106"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201068837\u2010y"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15060705"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00147"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.04.003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00880"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5c00024"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol2028288"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA19583K"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c18031"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/cs502126n"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC47336H"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02998"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011419\u2010y"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c07252"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201600906"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB00841H"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202200725"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0QO00563K"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/158448c0"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.10.008"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10863"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c02513"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001429\u20101"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010024\u201001728\u20101"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214508"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c21841"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ads3955"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC06087F"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2779-1020"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2288-6944"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010025\u201001458\u20108"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-025-01453-z"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja5080739"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77873","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77873","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:05:34Z","timestamp":1790532334000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":75,"alternative-id":["10.1002\/advs.77873"],"URL":"https:\/\/doi.org\/10.1002\/advs.77873","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2026-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77873"}}