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Changes in extracellular matrix (ECM) composition, particularly type I collagen density, significantly influence crucial cellular activities. However, the association between type I collagen density and TNBC progression remains unclear. This study finds that type I collagen density and mechanical characteristics of lesions predict the pathological grade and malignant progression of TNBC patients. The results of transcriptomics and metabolomics studies suggest that high\u2010density type I collagen promotes TNBC ferroptosis. Further in vitro experiments indicate that high\u2010density type I collagen promotes ferroptosis in TNBC cells through spermidine\/spermine N1\u2010acetyltransferase 1 (SAT1)\/argininosuccinate synthase (ASS1)\u2010induced glutamine (Gln) accumulation. Moreover, in vitro co\u2010culture and in vivo experiments reveal that high\u2010density type I collagen increases the uptake of Gln in TNBC cells, leading to Gln deprivation of IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the tumor microenvironment, resulting in higher level of immunosuppression. Combination of ferrostatin 1 and anti\u2010PD\u20101 therapy reverses high\u2010density collagen\u2010induced tumor progression of TNBC. The clinical samples further verify the role of collagen density in TNBC. This study reveals that high\u2010density type I collagen participates in TNBC progression partly through immunosuppression induced by Gln accumulation\u2010related ferroptosis.\n                  <\/jats:p>","DOI":"10.1002\/advs.77879","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Density Type I Collagen Promotes IFN\u2010\u03b3\n                    <sup>+<\/sup>\n                    CD8\n                    <sup>+<\/sup>\n                    T Cell Exhaustion via SAT1\u2010ASS1\u2010Mediated Glutamine Accumulation and Ferroptosis in Triple\u2010Negative Breast Cancer"],"prefix":"10.1002","author":[{"given":"Jinyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 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