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Here, network pharmacology combined with molecular docking suggested that the compound\n                    <jats:italic>Abrus cantoniensis<\/jats:italic>\n                    extract (ACCE) attenuates AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010induced hepatotoxicity via modulation of the PI3K\u2010AKT signaling pathway. This was validated through integrated transcriptomic, microbiomic, metabolomic, and in vivo\/in vitro analyses. In vivo, ACCE ameliorated hepatic and intestinal damage in AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010exposed mice, modulated PI3K\u2010AKT and TLR4\/NF\u2010\u03baB pathways, reshaped gut microbiota by enriching\n                    <jats:italic>Lachnospiraceae_NK4A136_group<\/jats:italic>\n                    , and increased short\u2010chain fatty acids (SCFAs), particularly butyrate. In vitro, ACCE activated PI3K\u2010AKT and suppressed TLR4\/NF\u2010\u03baB signaling in HepG2 cells, effects diminished by pathway inhibitors. Butyrate alone also protected against AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010induced injury via TLR4\/NF\u2010\u03baB inhibition, an effect similarly reversed by inhibitors. Notably, combined treatment with ACCE or its main components and butyrate yielded superior protection. Collectively, these findings suggest that ACCE can alleviate AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010induced liver injury by regulating the PI3K\u2010AKT pathway and the gut microbiota and its metabolite butyrate.\n                  <\/jats:p>","DOI":"10.1002\/advs.77889","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Compound\n                    <i>Abrus cantoniensis<\/i>\n                    Extract Alleviates AFB\n                    <sub>1<\/sub>\n                    \u2010Induced Liver Injury by Regulating PI3K\u2010AKT Pathway and Gut Microbiota\/Butyrate 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