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The sensitivity and specificity of existing clinical testing equipment for gallbladder malignancy remain insufficient. In this proof\u2010of\u2010concept pilot study, we developed a bio\u2010memristor featuring an Ag\/bile\/fluorine\u2010doped tin oxide structure using clinically sourced bile samples from a small clinical cohort and characterized its resistive switching behavior. The memristive electrical signatures, particularly negative peak current and the high\u2010resistance\u2010state to low\u2010resistance\u2010state ratio, differed systematically across people with normal gallbladder, cholelithiasis patients, and GBC patients, enabling a two\u2010step detection strategy. Within this pilot cohort, the detection performance was encouraging. These findings establish the technical feasibility of memristor\u2010based bile detection for gallbladder cancer and provide a foundation for developing detection technology that is expected to complement existing clinical approaches to improve gallbladder cancer identification.<\/jats:p>","DOI":"10.1002\/advs.77893","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bio\u2010Memristor Based on Clinical Bile Samples: A Proof\u2010of\u2010Concept Pilot Study for Detection of Gallbladder Cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5217-5957","authenticated-orcid":false,"given":"Junming","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Abdominal Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 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