{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:04:33Z","timestamp":1790784273801,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20251966"],"award-info":[{"award-number":["BK20251966"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["SJCX25\u20100927"],"award-info":[{"award-number":["SJCX25\u20100927"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Plant\u2010derived nanovesicles have emerged as promising natural nanotherapeutics for cancer treatment, yet whether they can overcome the intrinsic resistance of tumor cells to cytotoxic T\u2010cell\u2010mediated killing remains largely unexplored. Here, we show that lipid\u2010enriched\n                    <jats:italic>Platycodon grandiflorus<\/jats:italic>\n                    \u2010derived nanovesicles (PGNs) sensitize gastric cancer to immune attack through ferroptosis\u2010driven plasma membrane mechanical remodeling. Mechanistically, PGNs reprogram tumor lipid composition by coordinately suppressing the SLC7A11\u2010GPX4 antioxidant axis while delivering polyunsaturated fatty acids, particularly Gamma\u2010linolenic acid, thereby promoting glutathione depletion, lipid peroxidation, and ferroptosis. Transcriptomic analyses further revealed coordinated attenuation of malignant epithelial programs together with remodeling of membrane\u2010associated and glutathione metabolic pathways following PGN treatment. Fluorescence lifetime imaging microscopy and atomic force microscopy revealed concomitant increases in plasma membrane tension and cellular stiffness during ferroptosis, facilitating perforin pore formation and enhancing the susceptibility of gastric cancer cells to cytotoxic T\u2010cell\u2010mediated killing. Collectively, these findings establish a mechanistic link between ferroptosis\u2010driven membrane mechanical remodeling and tumor immune susceptibility, highlighting plant\u2010derived lipid nanovesicles as a promising natural strategy for enhancing antitumor immunity.\n                  <\/jats:p>","DOI":"10.1002\/advs.77900","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Platycodon grandiflorus<\/i>\n                    \u2013Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis\u2010Driven Membrane Mechanical Remodeling"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0130-1184","authenticated-orcid":false,"given":"Jian","family":"Wu","sequence":"first","affiliation":[{"name":"Jiangsu Province Key Laboratory of Tumor Systems Biology and 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Xing","sequence":"additional","affiliation":[{"name":"Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing Jiangsu China"},{"name":"No.1 Clinical Medical College Nanjing University of Chinese Medicine  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjing","family":"Ma","sequence":"additional","affiliation":[{"name":"Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing Jiangsu China"},{"name":"No.1 Clinical Medical College Nanjing University of Chinese Medicine  Nanjing Jiangsu 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-2250","authenticated-orcid":false,"given":"Qingmin","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing Jiangsu 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