{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:55:34Z","timestamp":1790790934767,"version":"4.1.0"},"reference-count":196,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["QH20230212"],"award-info":[{"award-number":["QH20230212"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tissue regeneration is an energy\u2010demanding process that requires adequate ATP production to support cellular proliferation, biosynthesis, and tissue remodeling. Under pathological and age\u2010related conditions, bioenergetic deficits impair intrinsic regenerative capacity by disrupting mitochondrial function, redox homeostasis, and anabolic signaling. Although conventional scaffold\u2010 and cell\u2010based bioengineering strategies have advanced regenerative medicine, they generally do not directly address the metabolic dysfunction that limits tissue repair. Recently, bioenergetic materials (BEMs) have emerged as a novel class of biomaterials engineered to modulate cellular metabolism in situ. By supplying tricarboxylic acid (TCA) cycle intermediates, delivering metabolic enzymes, or incorporating oxygen\u2010releasing and energy\u2010harvesting components, BEMs replenish cellular ATP, restore redox balance, and activate anabolic signaling pathways that support tissue regeneration. In this review, we classify BEMs according to their principal mechanisms of action and summarize recent advances in their application to bone, cartilage, skin, and neural tissue repair. We further discuss the major challenges to clinical translation and highlight future opportunities for integrating metabolic modulation with advanced fabrication techniques and smart, feedback\u2010regulated biomaterial systems. By reshaping the local metabolic microenvironments, BEMs represent a promising strategy to enhance tissue regeneration in pathological settings characterized by mitochondrial dysfunction, redox imbalance, inflammation, and insufficient energy supply.<\/jats:p>","DOI":"10.1002\/advs.77905","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3985-7779","authenticated-orcid":false,"given":"Yuchen","family":"He","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The Second Xiangya Hospital of Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology (Central South University) Ministry of Education, and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-7935","authenticated-orcid":false,"given":"Yuwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1235-0282","authenticated-orcid":false,"given":"Jonathan F.","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"School of Medicine University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-4103","authenticated-orcid":false,"given":"Yiting","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Department of Orthopedic Surgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-3915","authenticated-orcid":false,"given":"Fei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-4980","authenticated-orcid":false,"given":"Weihong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The Second Xiangya Hospital of Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology (Central South University) Ministry of Education, and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-6705","authenticated-orcid":false,"given":"Rocky S.","family":"Tuan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Institute for Tissue Engineering and Regenerative Medicine School of Biomedical Sciences The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6009-629X","authenticated-orcid":false,"given":"Zhong Alan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Institute for Tissue Engineering and Regenerative Medicine School of Biomedical Sciences The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Shun Hing Institute of Advanced Engineering (SHIAE) The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Key Laboratory of Regenerative Medicine School of Biomedical Sciences Ministry of Education The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Shenzhen Research Institute The Chinese University of Hong Kong  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-74932-7_1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101678\u20101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010022\u201000572\u2010w"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.33496"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf0115"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13981"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25986"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.03.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102499\u2010y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010023\u201000972\u2010y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001378\u20108"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043527\u20101"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.11.011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.037"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.04.037"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2693"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abk0011"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay7608"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.02.011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.07.043"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp7872"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900819"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u20100227\u2010y"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20250005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004475\u2010w"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24057"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000774\u20102"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102101"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202400201"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ady2862"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1813000115"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116060"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161\u2010024\u201000502\u20103"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010024\u201001143\u20103"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726\u2010016\u20102254\u20108"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123597"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c00263"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053398\u20109"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010025\u201002153\u20105"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.10.023"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.05.014"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108108"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c09394"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010020\u20100243\u20104"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.008"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u20100406\u20102"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122942"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c09202"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk9880"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045927\u20103"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056179\u20100"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015589\u2010y"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar400293h"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00011"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08013"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.12.019"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500810"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201003060\u20109"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12480"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c01832"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309060"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2025.103541"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21935"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.002"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.11.002"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18444"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c02923"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01480"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202505954"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szac044"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adv4238"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406287"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805038"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005499\u2010y"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.08.003"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmt\u20102021\u20100265"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040954\u2010y"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230003"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201601694"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301468"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105747"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413171"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402530"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09593"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c09971"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027217\u20104"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.08.023"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100472"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114421"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.123983"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c04717"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202411121"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c20688"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2020.3020283"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402871"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309875"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac008"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003795\u20107"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230011"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u201000279\u2010w"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010021\u201000736\u20104"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adv8804"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010017\u20100127\u20104"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03130"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010025\u201001972\u20107"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017\u201000064"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.01.003"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412867"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathmechdis\u2010031521\u2010040919"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c06979"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314241310541"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010019\u20100191\u20108"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.164950"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403009"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202202044"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002787\u20109"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c03446"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.08.008"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.22031"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010023\u201000302\u20108"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415459"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101773"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202522108"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.22047"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9080194"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2025.07.011"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101249"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/inmd.70055"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.96723"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102023\u2010224002"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122903"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16085"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503909"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2025.100913"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412817"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0306"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2022.03.006"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307338"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c04787"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202407813"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122036"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202202715"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411911"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202502677"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002965\u20109"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2018.09.001"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14151217"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305363"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR\u20102024\u20100083"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20240062"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201060858\u20103"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac014"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.05.008"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201058061\u20105"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c08336"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230019"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11177"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.029"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007429"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010022\u201001511\u2010z"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.01.017"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202402285"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.06.024"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.035"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.011"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00062.2017"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.34133\/2021\/9812523"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307081"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307896"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c07285"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123103"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c04341"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137887"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.02.034"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121990"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12502"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u2010605X\/aba326"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010010\u20101388\u20103"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304632"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.07.034"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2025.10.013"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2025.100667"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010025\u201002031\u20105"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.06.023"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010019\u20100068\u20103"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111193"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102024\u2010010371"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08346"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf039"},{"key":"e_1_2_10_195_1","first-page":"7038","article-title":"Urolithin A Protects Chondrocytes From Mechanical Overloading\u2010Induced Injuries","volume":"12","author":"He Y.","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158451"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009097\u20106"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77905","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:59:34Z","timestamp":1790787574000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":196,"alternative-id":["10.1002\/advs.77905"],"URL":"https:\/\/doi.org\/10.1002\/advs.77905","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77905"}}