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Achieving such functionality in synthetic materials remains challenging, as most energy\u2010driven molecular assembly only forms transient structures and cannot sustain operations under continuous energy input. Here, we report a bioelectrochemically powered hydrogel that operates far\u2010from\u2010equilibrium via a fully electrochemical antagonistic redox cycle coupled to enzymatic feedback. We establish a fully electrochemical cycle in which reduced vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    and oxidized ferrocene mediate disulfide cleavage and reformation within a disulfide\u2010cross\u2010linked polyrotaxane\u2010based hydrogel, enabling dissipative growth and temporal modulation of mechanical properties. Embedding glucose oxidase within the hydrogel introduces a glucose\u2010dependent enzymatic pathway that competes for ferrocene against disulfide reformation, inducing partial network decrosslinking and increased permeability under high\u2010glucose level. This enzymatic feedback mechanism enables a glucose\u2010responsive insulin delivery platform with enhanced release at high glucose and suppressed release at low glucose. These findings establish a general strategy to couple electrochemical energy input with biochemical feedback, enabling adaptive regulation of structure, mechanics and transport in soft materials under nonequilibrium conditions.\n                  <\/jats:p>","DOI":"10.1002\/advs.77934","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioelectrochemically Powered Out\u2010of\u2010Equilibrium Hydrogels Enable Feedback\u2010Regulated Functions"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6061-3448","authenticated-orcid":false,"given":"Roberto","family":"Baretta","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences University of Padova  Padova 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