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Although current treatments reduce proliferating tumor burden, residual cells may survive therapy and drive delayed relapse. This Review examines dormancy in ovarian, endometrial, and cervical cancers using entry, maintenance, and awakening as an organizing framework rather than a universally demonstrated sequence. Direct evidence is concentrated in ovarian cancer, whereas evidence in endometrial and cervical cancers remains predominantly indirect. We delineate candidate biological dependencies\u2014including redox control, lipid peroxidation buffering, mitochondrial plasticity, adaptive stress\u2010response programs, epigenetic and post\u2010transcriptional plasticity, immune regulation, and extracellular matrix remodeling\u2014rather than established vulnerabilities. On this basis, we evaluate two biologically distinct investigational concepts: suppression of reactivation\u2010associated signals to prolong clinical latency, and state modulation followed by biomarker\u2010defined treatment, discussed within established disease\u2010specific care pathways. Finally, we propose a translational framework combining longitudinal liquid biopsy with spatial and single\u2010cell profiling for MRD monitoring, biological stratification, and future probabilistic inference of residual\u2010cell states. Together, these concepts support a shift from reactive relapse treatment toward evidence\u2010 and risk\u2010constrained recurrence\u2010interception research and provide a framework for validating residual\u2010state biomarkers and therapeutic dependencies in gynecologic malignancies.<\/jats:p>","DOI":"10.1002\/advs.77941","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:31:25Z","timestamp":1792121485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-1570","authenticated-orcid":false,"given":"Shih\u2010Hsuan","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-6520","authenticated-orcid":false,"given":"Ren\u2010Wang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Inselspital Bern University Hospital  Bern Switzerland"},{"name":"Department of BioMedical Research (DBMR) University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Cheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zuoying Armed Forces General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-575X","authenticated-orcid":false,"given":"Chi\u2010Wen","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Breast Oncology and Surgery Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Naveen","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4411-044X","authenticated-orcid":false,"given":"Zhi\u2010Hong","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine National Sun Yat\u2010sen University  Kaohsiung Taiwan"},{"name":"National Museum of Marine Biology &amp; Aquarium  Pingtung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-9970","authenticated-orcid":false,"given":"Tzu\u2010Hung","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Public Health Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Institute of Genomics and Bioinformatics National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3773-9015","authenticated-orcid":false,"given":"Chia\u2010Jung","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"National Museum of Marine Biology &amp; Aquarium  Pingtung Taiwan"},{"name":"Institute of Biopharmaceutical Sciences National Sun Yat\u2010sen University  Kaohsiung Taiwan"},{"name":"Center of General Education Cheng Shiu University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"11","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/ncb2861","article-title":"TGF\u2010\u03b22 Dictates Disseminated Tumour Cell Fate in Target Organs Through TGF\u2010\u03b2\u2010RIII and p38\u03b1\/\u03b2 Signalling","volume":"15","author":"Bragado P.","year":"2013","journal-title":"Nature Cell Biology"},{"issue":"10","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/s41416-023-02401-z","article-title":"A Cell Cycle Centric View of Tumour Dormancy","volume":"129","author":"Weston W. 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