{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:00:24Z","timestamp":1790787624714,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471314"],"award-info":[{"award-number":["82471314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Subarachnoid hemorrhage (SAH) causes long\u2010term cognitive dysfunction due to early brain injury, but effective therapies are limited. Remote ischemic post\u2010conditioning (RIPostC) confers neuroprotection, but its mechanisms remain incompletely understood. Here we show that RIPostC preserves the neurovascular unit by modulating monocyte\u2010derived macrophages (MDMs) via the Gas6\/Axl\/Vimentin axis. In 405 SAH patients, elevated cerebrospinal fluid leukocyte counts correlate positively with Hunt\u2010Hess and 3\u2010month mRS scores. In a rat SAH model, RIPostC suppresses periventricular CCR2\n                    <jats:sup>+<\/jats:sup>\n                    cell infiltration, reduces MDMs, shifts their polarization from M1\u2010like to M2\u2010like, preserves blood\u2010brain barrier integrity, and improves cognitive function. Mechanistically, RIPostC downregulates Vimentin. However, the Vimentin inhibitor Withaferin A mimics anti\u2010infiltration but does not promote M2\u2010like polarization. RIPostC upregulates neuronal Gas6, which engages MDM Axl. Besides, Gas6 knockdown abolishes RIPostC's protective effects. Additionally, RIPostC selectively expands a reparative Stab1\n                    <jats:sup>+<\/jats:sup>\n                    Clec10a\n                    <jats:sup>+<\/jats:sup>\n                    MDM subset. In human THP\u20101 cells, recombinant Gas6 suppresses Vimentin and induces M2\u2010like polarization via Axl, and the Axl inhibitor R428 blocks this effect. Thus, RIPostC enhances neuronal Gas6 to activate MDM Axl and downregulate Vimentin, limiting infiltration and driving reparative polarization, which preserves neurovascular unit integrity and improves cognition after SAH.\n                  <\/jats:p>","DOI":"10.1002\/advs.77946","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remote Ischemic Post\u2010Conditioning Preserves the Neurovascular Unit by Brain\u2010Derived Gas6 That Drives Monocyte\u2010Derived Macrophage Reprogramming via Axl and Vimentin after SAH"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9153-9930","authenticated-orcid":false,"given":"Yajun","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Rong","sequence":"additional","affiliation":[{"name":"West China Hospital Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwei","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuming","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-9665","authenticated-orcid":false,"given":"Jiru","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2054-8569","authenticated-orcid":false,"given":"Yifan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Diseases Suining Central Hospital  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-1362","authenticated-orcid":false,"given":"Jin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-0487","authenticated-orcid":false,"given":"Hongji","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Diseases Suining Central Hospital  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-9293","authenticated-orcid":false,"given":"Zongduo","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046015\u20102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873241232823"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010024\u201007387\u20107"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.122.040072"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010025\u201005640\u2010z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.12.152"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.597914"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010025\u201003444\u20100"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010025\u201003631\u2010z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00116\u201024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/nrr.Nrr\u2010d\u201024\u201001037"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmr.2025.100052"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/nrr.Nrr\u2010d\u201023\u201001800"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975\u2010024\u201001235\u2010y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010025\u201003587\u20100"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10590"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.123.046144"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211006580"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf570"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103684"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(24)00369\u20107"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231184806"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201002939\u2010y"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010025\u201002406\u2010x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010025\u201004889\u20103"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930221104710"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2026.103900"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114964"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u20103123234\/v1"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.03.002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096\u20109861(20000918)425:2<295::aid\u2010cne11>3.0.co;2\u2010g"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(98)01159\u20107"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010032414\u2010112103"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147525"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201002940\u20105"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201002921\u20108"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.363187"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.742359"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231205078"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.355744"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010024\u201002210\u20109"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae178"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2012.07823.x"},{"issue":"4","key":"e_1_2_9_45_1","first-page":"1625","article-title":"Expression of Stabilin\u20101 in M2 Macrophages in Human Granulomatous Disease and Melanocytic Lesions","volume":"7","author":"Schoenhaar K.","year":"2014","journal-title":"International journal of clinical and experimental pathology"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci12121168"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.049569"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.110104"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46100650"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.04.15.589568"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104375"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11041163"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13663"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.2176\/jns\u2010nmc.2025\u20100111"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010024\u201002111\u20101"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010025\u201002952\u2010w"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.115.010088"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114809"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1158758"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77946","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:24:39Z","timestamp":1790785479000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":58,"alternative-id":["10.1002\/advs.77946"],"URL":"https:\/\/doi.org\/10.1002\/advs.77946","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77946"}}