{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:01:22Z","timestamp":1790787682585,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1104505"],"award-info":[{"award-number":["2023YFF1104505"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sarcopenia has emerged as a major health challenge in the aging population. Whey protein (WP)\u2014rich in branched\u2010chain amino acids\u2014is an important nutritional supplement for mitigating sarcopenia. However, the rapid digestion of WP limits its therapeutic efficacy. Developing a sustained\u2010release system for WP may enhance its effectiveness in mitigating sarcopenia. Herein, a novel \u201csingle\u2010protein particle encapsulation\u201d (SPPE) system is developed to protect WP and control its release. Specifically, the \u201cmolecular glue\u201d metal\u2013polyphenol networks (MPNs) are assembled onto the surface of individual polymerized WP isolate (PWPI) particles as an intermediate layer and bridged with the saccharide hyaluronic acid (HA) to construct PWPI@MPNs\/HA. The results showed that PWPI@MPNs\/HA precisely regulates the release rate of PWPI in the gastrointestinal tract. In a murine sarcopenia model, PWPI@MPNs25\/HA significantly improves lean body content, grip strength, grid hanging time, exhaustion time, and exhaustion distance. The underlying molecular mechanism involves activation of the PI3K\/AKT\/mTOR signaling pathway and suppression of the muscle atrophy factors\n                    <jats:italic>MuRF\u20101<\/jats:italic>\n                    and\n                    <jats:italic>Atrogin\u20101<\/jats:italic>\n                    in the ubiquitin\u2013proteasome system via PWPI@MPNs\/HA. The SPPE system developed in this study may have broad future applications in protein protection and delivery.\n                  <\/jats:p>","DOI":"10.1002\/advs.77951","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developing Metal\u2013Polyphenol Network\u2010Based Single\u2010Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-847X","authenticated-orcid":false,"given":"Yafei","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5636-8770","authenticated-orcid":false,"given":"Yuning","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Ai","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8426-477X","authenticated-orcid":false,"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Quan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-5556","authenticated-orcid":false,"given":"Xiaoxu","family":"Zhang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4404-8390","authenticated-orcid":false,"given":"Yingying","family":"Lin","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-3275","authenticated-orcid":false,"given":"Sijia","family":"Song","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-177X","authenticated-orcid":false,"given":"Huiyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-26576-1_6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"M. 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