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Herein, we report a C\n                    <jats:sub>3<\/jats:sub>\n                    \u2010symmetric conjugate (\n                    <jats:bold>TASe<\/jats:bold>\n                    ) that unites benzoselenadiazole, alanine, and acylhydrazone motifs, each serving dual roles as both supramolecular interaction sites and bioactive pharmacophores. This multifunctional design enables synergistic noncovalent assembly through cooperative chalcogen and hydrogen bonds, which direct the formation of a porous crystalline framework. In aqueous media, the same molecular modules drive self\u2010assembly into uniform chiral nanospheres. The resulting assemblies efficiently protect cardiomyocytes from doxorubicin\u2010induced injury by scavenging reactive oxygen species, reducing oxidative DNA damage, and attenuating ERK activation, without compromising anticancer efficacy. By embedding both assembly\u2010directing and therapeutic functions within a single molecular scaffold, this work provides a generalizable strategy for constructing biologically active supramolecular materials with coordinated structural order and function.\n                  <\/jats:p>","DOI":"10.1002\/advs.77953","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supramolecular Chiral Assemblies from Benzoselenadiazole\u2010Alanine\u2010Acylhydrazone Conjugates Enable Cardioprotection"],"prefix":"10.1002","author":[{"given":"Jinkui","family":"Teng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases Xiang an Biomedicine Laboratory Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical Sciences Xiamen 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