{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:54:38Z","timestamp":1790790878131,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82293660\/82293665"],"award-info":[{"award-number":["82293660\/82293665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232246"],"award-info":[{"award-number":["7232246"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    STING agonists (e.g., cGAMP), which function as immunotherapeutic agents activating the stimulator of interferon genes (STING) pathway, hold promise for treating pediatric solid tumors including neuroblastoma. However, their clinical translation is hindered by limitations including burst release, short half\u2010life, poor targeting, and low intracellular delivery efficiency. In this study, we engineered a peptide self\u2010assembled nanofiber (NFSA) based on the specific interaction mechanism between STING protein and cGAMP. By hydrophobically modifying the cGAMP\u2010binding amino acid sequences on STING, two amphiphilic peptides, MP1 and MP2, were obtained, which self\u2010assembled into nanofibers to efficiently encapsulate cGAMP. The NFSA showed excellent biocompatibility and low toxicity both in vitro and in vivo. It enabled pH\u2010responsive cGAMP release, promoted cellular uptake, enhanced the endoplasmic reticulum (ER) localization, and activated the STING pathway. NFSA also promoted dendritic cell maturation and shifted tumor\u2010associated macrophages to the anti\u2010tumor M1 type. In vivo, NFSA reduced neuroblastoma growth, increased CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration, induced tumor cell apoptosis, and demonstrated good biosafety. Our study developed a novel, easily producible, and low\u2010toxicity STING agonist nanodelivery platform, which effectively overcomes key pharmacokinetic and pharmacodynamic barriers limiting clinical translation and provides a new strategy for efficient STING agonist delivery and immunotherapy of pediatric solid tumors.\n                  <\/jats:p>","DOI":"10.1002\/advs.77967","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineered Peptide Self\u2010Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors"],"prefix":"10.1002","author":[{"given":"Yubin","family":"He","sequence":"first","affiliation":[{"name":"Department of Pharmacy National Center for Children's Health Beijing Children's Hospital Capital Medical University  Beijing China"},{"name":"School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Center for Children's Health Beijing Children's Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang qing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Center for Children's Health Beijing Children's Hospital Capital Medical University  Beijing China"},{"name":"School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8211-0849","authenticated-orcid":false,"given":"Bo","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Center for Children's Health Beijing Children's Hospital Capital Medical University  Beijing China"},{"name":"School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-2600","authenticated-orcid":false,"given":"Xin","family":"Ni","sequence":"additional","affiliation":[{"name":"National Center for Pediatric Cancer Surveillance National Center for Children's Health Beijing Children's Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-8702","authenticated-orcid":false,"given":"Dong","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Center for Children's Health Beijing Children's Hospital Capital Medical University  Beijing China"},{"name":"Clinical Research Ward Capital Center for Children's Health Capital Institute of Pediatrics Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102600"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201021\u20101356"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102024\u2010009063"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.38425"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abn6612"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.22016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201022\u20100483"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004559\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188983"},{"key":"e_1_2_10_11_1","article-title":"Bioactivable 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