{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:59:07Z","timestamp":1790794747463,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32674071"],"award-info":[{"award-number":["32674071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013156","name":"Startup Foundation for Introducing Talent of Nanjing University of Information Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immune gene families frequently produce numerous non\u2010coding transcripts, yet their biological functions remain largely unexplored. Here, using the arthropod\n                    <jats:italic>immunoglobulin domain\u2010containing lectin<\/jats:italic>\n                    (\n                    <jats:italic>IgLec<\/jats:italic>\n                    ) family as a paradigm, we provide evidence that this complexity may reflect a critical defensive function for non\u2010coding transcripts in antiviral immunity.\n                    <jats:italic>IgLec<\/jats:italic>\n                    is restricted to decapod infraorders (Brachyura and Astacidea), and a structurally related bacterial homolog suggests its origin may involve horizontal gene transfer. The\n                    <jats:italic>IgLec<\/jats:italic>\n                    family generates extraordinary transcript diversity through three mechanisms, multi\u2010locus duplication, inter\u2010locus recombination, and extensive alternative splicing, yielding both protein\u2010coding and non\u2010coding transcripts. Protein\u2010coding IgLec variants restrict viral replication by inducing\n                    <jats:italic>antimicrobial peptide<\/jats:italic>\n                    expression. Upon white spot syndrome virus infection, non\u2010coding transcripts (e.g., intron\u2010retaining transcripts) are preferentially targeted by virus\u2010encoded microRNA\u2010N48, thereby protecting protein\u2010coding isoforms from repression. Loss of these decoy transcripts compromises antiviral defense and increases host mortality. Collectively, these results reveal a decoy\u2010based antiviral strategy in which non\u2010coding transcripts safeguard immune effectors from pathogen subversion, uncovering an unrecognized layer of innate immunity.\n                  <\/jats:p>","DOI":"10.1002\/advs.77981","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Coding Transcripts From Diversified Members of IgLec Family Protect Antiviral Effectors From Viral miRNA"],"prefix":"10.1002","author":[{"given":"Ying","family":"Huang","sequence":"first","affiliation":[{"name":"Jiangsu Province Engineering Research Center For Marine Bio\u2010Resources Sustainable Utilization, College of Oceanography Hohai University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Province Engineering Research Center For Marine Bio\u2010Resources Sustainable Utilization, College of Oceanography Hohai University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangsu Province Engineering Research Center For Aquatic Animals Breeding and Green Efficient Aquacultural Technology, College of Marine Science and Engineering Nanjing Normal University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u2010Qin","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Climate System Prediction and Risk Management, School of Marine Sciences Nanjing University of Information Science and Technology  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang\u2010Feng","family":"Lan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Shandong Provincial Key Laboratory of Zoonoses Shandong Agricultural University  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-5697","authenticated-orcid":false,"given":"Qian","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Climate System Prediction and Risk Management, School of Marine Sciences Nanjing University of Information Science and Technology  Nanjing 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