{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:18Z","timestamp":1791355938967,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC82272010 NSFC82630056"],"award-info":[{"award-number":["NSFC82272010 NSFC82630056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Herein, we developed a novel non\u2010invasive therapeutic strategy, namely ultrasound\u2010triggered cavitation of diagnostic\u2010grade microbubbles (MBs), which delivers favorable rhythmic mechanical stimuli to reverse this core pathological defect of diabetic kidney disease (DKD). By systematically optimizing parameters between low\u2010intensity pulsed ultrasound (LIPUS) and the clinically approved diagnostic MB contrast agent Sonazoid, we established a standardized protocol (Sonazoid: 0.008\u00a0\u00b5g per injection; LIPUS: 3.4\u20104.1\u00a0MHz, mechanical index 0.2; 10 min per session, twice weekly for 4 weeks) to precisely deliver localized favorable rhythmic mechanical stimuli to the renal microvasculature. In the db\/db mouse model of progressive DKD, this therapeutic intervention significantly improved renal function, reduced albuminuria, and mitigated glomerular and tubular histological lesions. Ultrasound localization microscopy (ULM) verified a remarkable enhancement in renal cortical microcirculatory perfusion. Transcriptomic profiling of renal tissues revealed down\u2010regulation of key pathways involved in endothelial dysfunction, leukocyte chemotaxis, and fibrosis, accompanied by a shift toward an anti\u2010inflammatory and anti\u2010fibrotic phenotypic state. Our findings demonstrate that this therapeutic strategy generates favorable mechanical modulation at the microvascular level, effectively retarding DKD progression by restoring microvascular homeostasis and suppressing pathogenic inflammatory and fibrotic cascades. This approach offers a promising and translational platform technology for the management of microvascular diseases beyond DKD.<\/jats:p>","DOI":"10.1002\/advs.77989","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:21:36Z","timestamp":1791354096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010Intensity Ultrasound\u2010Triggered Microbubble Cavitation Attenuates Diabetic Kidney Injury Partially by Reversing Endothelial Dysfunction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3747-4209","authenticated-orcid":false,"given":"Yubo","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine Tangdu Hospital Fourth Military Medical University  Shaanxi 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