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A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signaling and uncontrolled viral replication. Multiple viral proteins and hijacked host proteins contribute to immune evasion, representing potential therapeutic targets. Here, we identify viral ORF9b as a conserved accessory protein across the\n                    <jats:italic>Sarbecovirus<\/jats:italic>\n                    subgenus that consistently suppresses innate immune responses by recruiting the protein phosphatase, Mg\n                    <jats:sup>2+<\/jats:sup>\n                    \/Mn\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010dependent 1A (PPM1A). Mechanistically, PPM1A exerts dual roles by directly dephosphorylating ORF9b and indirectly downregulating STAT2 phosphorylation, thereby suppressing RIG\u2010I\/MAVS and JAK\u2010STAT signaling pathways. The PPM1A inhibitor SMIP\u2010031 inhibits coronavirus replication and restores the antiviral innate immune homeostasis. These findings reveal a conserved immune\u2010evasion strategy in sarbecoviruses and highlight the ORF9b\u2010PPM1A axis as a potential target for broad\u2010spectrum sarbecovirus therapeutics to help prevent future pandemics.\n                  <\/jats:p>","DOI":"10.1002\/advs.78023","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation"],"prefix":"10.1002","author":[{"given":"Lixiang","family":"Xie","sequence":"first","affiliation":[{"name":"Institute of Human Virology Zhongshan School of Medicine Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangzhou National Laboratory Guangzhou International Bio\u2010Island  Guangzhou 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