{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:00:10Z","timestamp":1790830810182,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371223"],"award-info":[{"award-number":["82371223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571349"],"award-info":[{"award-number":["82571349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20357"],"award-info":[{"award-number":["U21A20357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970995"],"award-info":[{"award-number":["81970995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401402"],"award-info":[{"award-number":["82401402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["25X010202804"],"award-info":[{"award-number":["25X010202804"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Perioperative neurocognitive disorders (PND) are a prevalent and disabling complication in elderly patients after anesthesia and surgery, imposing a growing clinical burden in aging societies.\u00a0Despite its high incidence, effective therapies for PND remain unavailable. Surgery\u2010induced neuroinflammation, characterized by excessive oxidative stress, microglial activation, and blood\u2010brain barrier (BBB) disruption, plays a central role in the development of PND. Here, we develop a PCN biomimetic nanozyme platform based on homologous, highly adhesive neutrophil membrane\u2010encapsulated Pd\/hCeO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles for the treatment of age\u2010related PND. Benefiting from the innate inflammation\u2010targeting properties of neutrophil membranes, PCN efficiently traverses the compromised BBB and precisely accumulates in neuroinflammatory regions. PCN exhibits potent reactive oxygen species scavenging activity and markedly attenuates neuroinflammation in the aging brain, while preserving BBB integrity. Specifically, PCN suppresses the pro\u2010inflammatory and dysmetabolic state of microglia through inhibition of the glycolytic pathway and promotion of aerobic respiration, thereby protecting synaptic function and improving cognitive performance in aged PND mice.\u00a0In general, this study identifies a biomimetic nanozyme strategy as a promising therapeutic approach for mitigating postoperative cognitive decline or other inflammatory damage in the aging brain.\n                  <\/jats:p>","DOI":"10.1002\/advs.78033","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:24:08Z","timestamp":1790828648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Neutrophil Membrane\u2010Encapsulated Pd\/hCeO\n                    <sub>2<\/sub>\n                    Nanoformulation for Alleviating Age\u2010Dependent Perioperative Neurocognitive Disorders"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7928-8725","authenticated-orcid":false,"given":"Lili","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"},{"name":"Key Laboratory of Anesthesiology (Shanghai Jiao Tong University) Ministry of Education  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7068-4992","authenticated-orcid":false,"given":"Huan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Pulmonary Hospital Tongji University School of Medicine  Yangpu Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8671-4659","authenticated-orcid":false,"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Shanghai Sixth People's Hospital Shanghai Jiao Tong University School of Medicine  Xuhui Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0959-9178","authenticated-orcid":false,"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4047-5877","authenticated-orcid":false,"given":"Yizhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"},{"name":"Key Laboratory of Anesthesiology (Shanghai Jiao Tong University) Ministry of Education  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanbing","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"},{"name":"Key Laboratory of Anesthesiology (Shanghai Jiao Tong University) Ministry of Education  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Xiong","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Shanghai Sixth People's Hospital Shanghai Jiao Tong University School of Medicine  Xuhui Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology Shanghai Sixth People's Hospital Shanghai Jiao Tong University School of Medicine  Xuhui Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"},{"name":"College of Health Science and Technology Shanghai Jiao Tong University School of Medicine  Huangpu Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"},{"name":"Key Laboratory of Anesthesiology (Shanghai Jiao Tong University) Ministry of Education  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9476-3073","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Anesthesiology (Shanghai Jiao Tong University) Ministry of Education  Pudong Shanghai China"},{"name":"Department of Radiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-1025","authenticated-orcid":false,"given":"Diansan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Renji Hospital Shanghai Jiao Tong University School of Medicine  Pudong Shanghai China"},{"name":"Key Laboratory of Anesthesiology (Shanghai Jiao Tong University) Ministry of Education  Pudong Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"9106","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(97)07382-0","article-title":"Long\u2010Term Postoperative Cognitive Dysfunction in the Elderly: ISPOCD1 Study","volume":"351","author":"Moller J. T.","year":"1998","journal-title":"The Lancet"},{"issue":"6","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJM200102083440601","article-title":"Longitudinal Assessment of Neurocognitive Function After Coronary\u2010Artery Bypass Surgery","volume":"344","author":"Newman M. F.","year":"2001","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/ALN.0000000000002334","article-title":"Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery\u20142018","volume":"129","author":"Evered L.","year":"2018","journal-title":"Anesthesiology"},{"issue":"3","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/ALN.0b013e318195b569","article-title":"Long\u2010Term Consequences of Postoperative Cognitive Dysfunction","volume":"110","author":"Steinmetz J.","year":"2009","journal-title":"Anesthesiology"},{"issue":"4","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1213\/ANE.0000000000004053","article-title":"Neuroinflammation and Perioperative Neurocognitive Disorders","volume":"128","author":"Subramaniyan S.","year":"2019","journal-title":"Anesthesia & Analgesia"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12916-022-02705-6","article-title":"Prolonged Anesthesia Induces Neuroinflammation and Complement\u2010Mediated Microglial Synaptic Elimination Involved in Neurocognitive Dysfunction and Anxiety\u2010Like Behaviors","volume":"21","author":"Xu F.","year":"2023","journal-title":"BMC Medicine"},{"issue":"1","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12974-022-02656-y","article-title":"Targeting Neuroinflammation as a Preventive and Therapeutic Approach for Perioperative Neurocognitive Disorders","volume":"19","author":"Cheng C.","year":"2022","journal-title":"Journal of Neuroinflammation"},{"issue":"1","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/JS9.0000000000000001","article-title":"Preventing Postoperative Cognitive Dysfunction Using Anesthetic Drugs in Elderly Patients Undergoing Noncardiac Surgery: A Systematic Review and Meta\u2010Analysis","volume":"109","author":"Zeng K.","year":"2023","journal-title":"International Journal of Surgery"},{"issue":"3","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bja.2025.05.035","article-title":"Effects of Ketamine on Postoperative Cognition: A Scoping Review","volume":"135","author":"Brenna C. T. A.","year":"2025","journal-title":"British Journal of Anaesthesia"},{"issue":"2","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/ALN.0000000000004439","article-title":"Prevention of Postoperative Cognitive Dysfunction by Minocycline in Elderly Patients After Total Knee Arthroplasty: A Randomized, Double\u2010Blind, Placebo\u2010Controlled Clinical Trial","volume":"138","author":"Takazawa T.","year":"2023","journal-title":"Anesthesiology"},{"issue":"1","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12974-019-1582-5","article-title":"The Broad Spectrum Mixed\u2010Lineage Kinase 3 Inhibitor URMC\u2010099 Prevents Acute Microgliosis and Cognitive Decline in a Mouse Model of Perioperative Neurocognitive Disorders","volume":"16","author":"Miller\u2010Rhodes P.","year":"2019","journal-title":"Journal of Neuroinflammation"},{"issue":"26","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"16450","DOI":"10.1021\/acsnano.4c03425","article-title":"Nanozymes: Potential Therapies for Reactive Oxygen Species Overproduction and Inflammation in Ischemic Stroke and Traumatic Brain injury","volume":"18","author":"Yang Y.","year":"2024","journal-title":"ACS Nano"},{"issue":"4","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1039\/C8CS00457A","article-title":"Nanomaterials With Enzyme\u2010Like Characteristics (Nanozymes): Next\u2010Generation Artificial Enzymes (II)","volume":"48","author":"Wu J.","year":"2019","journal-title":"Chemical Society Reviews"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.mattod.2022.11.007","article-title":"Self\u2010Therapeutic Nanomaterials: Applications in Biology and Medicine","volume":"62","author":"Seaberg J.","year":"2022","journal-title":"Materials 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Research"},{"issue":"20","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.3390\/nano13202803","article-title":"The Impressive Anti\u2010Inflammatory Activity of Cerium Oxide Nanoparticles: More Than Redox?","volume":"13","author":"Corsi F.","year":"2023","journal-title":"Nanomaterials"},{"issue":"34","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202504436","article-title":"Cerium Oxide Nanozymes: Exploring Synthesis, Catalytic Activity, and Biomedical Potential","volume":"21","author":"Cai Y.","year":"2025","journal-title":"Small"},{"issue":"10","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"14147","DOI":"10.1021\/acsanm.2c03009","article-title":"Nanoceria\u2010Based Artificial Nanozymes: Review of Materials and Applications","volume":"5","author":"Xiao G.","year":"2022","journal-title":"ACS Applied Nano Materials"},{"issue":"1","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12951-019-0516-9","article-title":"Synthesis and Biomedical Applications of Nanoceria, a Redox Active Nanoparticle","volume":"17","author":"Thakur N.","year":"2019","journal-title":"Journal of Nanobiotechnology"},{"issue":"12","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"20567","DOI":"10.1021\/acsnano.2c07306","article-title":"Nanoceria as an Electron Reservoir: Spontaneous Deposition of Metal Nanoparticles on Oxides and Their Anti\u2010Inflammatory Activities","volume":"16","author":"Muhammad F.","year":"2022","journal-title":"ACS Nano"},{"issue":"10","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"11552","DOI":"10.1021\/acsnano.9b05075","article-title":"Nanozyme\u2010Based Bandage With Single\u2010Atom Catalysis for Brain Trauma","volume":"13","author":"Yan R.","year":"2019","journal-title":"ACS 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