{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:51:06Z","timestamp":1791355866198,"version":"4.3.1"},"reference-count":109,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Changes to gut microbiomes are linked to inflammatory bowel disease, but little is known about how microbial change is modulated in complex gut microbiota systems. Here, we address this issue by revealing the influence of microbial interactions on gut microbiota response to ulcerative colitis (UC) using a spouse\u2010pair cohort design composed of an UC patient and his healthy spouse living in the same household environment. We calculate the difference in abundance of a microbial species between each pair of spouses as a proxy of UC\u2010induced phenotypic plasticity (uPP). We classify all microbes into functionally distinct modules based on the similarity of uPP across household environments. An integrative network and GLMY homology analysis identifies a pathobiont\u2010centric hub module and its disease\u2010specific topological motifs, characterized by UC\u2010associated microbial dysbiosis. We find that a marked increase in microbial plasticity is mediated by profound restructuring of microbial interactomes in the microbial communities. By inferring multilayer interactome networks, our model positions phenotypic plasticity as a systematic mechanistic force of UC, paving the way for its ecology\u2010informed diagnostics and interventions.<\/jats:p>","DOI":"10.1002\/advs.78043","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:07:27Z","timestamp":1791353247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6608-856X","authenticated-orcid":false,"given":"Huizhen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital  Tianjin China"},{"name":"Department of Gastroenterology Integrative Microecology Clinical Center Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease Shenzhen Clinical Research Center for Digestive Disease Shenzhen Technology Research Center of Gut Microbiota Transplantation Shenzhen Hospital of Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Dong","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Topological Statistics and Applications for Complex Systems Beijing Institute of Mathematical Sciences and Applications  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital  Tianjin China"},{"name":"Department of Gastroenterology Integrative Microecology Clinical Center Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease Shenzhen Clinical Research Center for Digestive Disease Shenzhen Technology Research Center of Gut Microbiota Transplantation Shenzhen Hospital of Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital  Tianjin China"},{"name":"Department of Gastroenterology Integrative Microecology Clinical Center Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease Shenzhen Clinical Research Center for Digestive Disease Shenzhen Technology Research Center of Gut Microbiota Transplantation Shenzhen Hospital of Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6039-1434","authenticated-orcid":false,"given":"Haojia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital  Tianjin China"},{"name":"Department of Gastroenterology Integrative Microecology Clinical Center Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease Shenzhen Clinical Research Center for Digestive Disease Shenzhen Technology Research Center of Gut Microbiota Transplantation Shenzhen Hospital of Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital  Tianjin China"},{"name":"Department of Gastroenterology Integrative Microecology Clinical Center Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease Shenzhen Clinical Research Center for Digestive Disease Shenzhen Technology Research Center of Gut Microbiota Transplantation Shenzhen Hospital of Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Hao","sequence":"additional","affiliation":[{"name":"Bellevue High School  Bellevue Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Gong","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Topological Statistics and Applications for Complex Systems Beijing Institute of Mathematical Sciences and Applications  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Meng","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Topological Statistics and Applications for Complex Systems Beijing Institute of Mathematical Sciences and Applications  Beijing China"},{"name":"Institute of Statistics and Big Data Renmin University of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Topological Statistics and Applications for Complex Systems Beijing Institute of Mathematical Sciences and Applications  Beijing China"},{"name":"Institute of Statistics and Big Data Renmin University of China  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing\u2010Tung","family":"Yau","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Topological Statistics and Applications for Complex Systems Beijing Institute of Mathematical Sciences and Applications  Beijing China"},{"name":"Yau Mathematical Sciences Center Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital  Tianjin China"},{"name":"Department of Gastroenterology Integrative Microecology Clinical Center Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease Shenzhen Clinical Research Center for Digestive Disease Shenzhen Technology Research Center of Gut Microbiota Transplantation Shenzhen Hospital of Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8350-7779","authenticated-orcid":false,"given":"Rongling","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Topological Statistics and Applications for Complex Systems Beijing Institute of Mathematical Sciences and Applications  Beijing China"},{"name":"Yau Mathematical Sciences Center Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.035"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2974"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010025\u201002399\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13326"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010025\u201004140\u20102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010024\u201005077\u2010y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558\u20105646.1998.tb01826.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025086\u20105"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhae172"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.120.303163"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ele.13862"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ele.14370"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.20.110189.001341"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.24.110193.000343"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.17.110186.003315"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u2010142x.2003.03015.x"},{"key":"e_1_2_10_18_1","volume-title":"Phenotypic Plasticity: Functional and Conceptual Approaches","author":"Schlichting C. D.","year":"2004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhac135"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.08.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.17179\/excli2025\u20108374"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhaf302"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2832"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2025.01.013"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41540\u2010019\u20100116\u20101"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082086"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2021.01.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041\u2010210x.14172"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2106103"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2308496120"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/246015a0"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000719\u2010y"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","DOI":"10.1201\/9780429425134","volume-title":"Graph Theory and Its Applications","author":"Gross J. L.","year":"2018"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2559119"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.294"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i19.106406"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1624539"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr070"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10832"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphys2162"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102012\u201013\u201012\u2010r112"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal4122"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plrev.2011.02.003"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.108.093690"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbr032"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102022\u2010328048"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010017\u20100490\u20105"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1430001"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjae028"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201055845\u20107"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2249152"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522\u2010021\u201000248\u2010x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102275"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1103836"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad014"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904099116"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9040697"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c03375"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2016.05.004"},{"key":"e_1_2_10_61_1","unstructured":"A.Grigor'yan Y.Lin Y.Muranov andS.\u2010T.Yau \u201cHomologies of Path Complexes and Digraphs \u201d preprint arXiv May 11 2013 https:\/\/arxiv.org\/abs\/1207.2834."},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.4310\/PAMQ.2014.v10.n4.a2"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10958\u2010020\u201004897\u20109"},{"key":"e_1_2_10_64_1","doi-asserted-by":"crossref","unstructured":"S.WuandM.Zhang \u201cDisentangling Complex Systems: IdopNetwork Meets GLMY Homology Theory \u201d preprint May 7 2025.","DOI":"10.4310\/DAAT.250513012010"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2412220121"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2024.10.006"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12485"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2028366"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00809"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0589"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2005.08.002"},{"key":"e_1_2_10_72_1","first-page":"115","volume-title":"Advances in Genetics","author":"Bradshaw A. D.","year":"1965"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1360\u20101385(00)01797\u20100"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20021463"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010020\u20100685\u20101"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010016\u20100331\u2010y"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102881\u20109"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.012"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062503"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/ele.14192"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1013213"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010020\u201001547\u20103"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.15698\/mic2024.03.817"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2025.111500"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4526"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.048"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaf185"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201025034\u20102"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13851"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.08.029"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462\u20102920.13659"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010019\u20100747\u2010x"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010ecolsys\u2010102723\u2010054525"},{"key":"e_1_2_10_94_1","volume-title":"Theory of Games and Economic Behavior, 2nd Rev","author":"Von Neumann J.","year":"1947"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.36.1.48"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u20109822(99)80321\u20102"},{"key":"e_1_2_10_97_1","volume-title":"Game Theory and Animal Behavior","author":"Hammerstein P.","year":"1998"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.es.09.110178.001543"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105193(03)00032\u20108"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.105.054775"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201012521\u20101"},{"key":"e_1_2_10_102_1","first-page":"389","article-title":"The Origin of Sparsity in the Interaction Networks of Living Systems","volume":"24","author":"Busiello D. M.","year":"2017","journal-title":"Planary Lectures and Boltzmann Medal Winners"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2309575121"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/35019019"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/238413a0"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1996.tb02080.x"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214506000000735"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2008.05.006"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystems.2021.104586"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2267"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.78043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:07:31Z","timestamp":1791353251000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":109,"alternative-id":["10.1002\/advs.78043"],"URL":"https:\/\/doi.org\/10.1002\/advs.78043","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2026-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e78043"}}