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Inspired by the mutable dermis of sea cucumbers, a collagen\u2013alginate double\u2010network elastomeric (CoDE) hydrogel integrates a covalently crosslinked collagen cryogel scaffold with an ionically crosslinked alginate sacrificial network. This hydrogel system is inherently biocompatible and biodegradable. Compression\u2010induced scaffold densification and ionic locking enable broad tuning of the compressive response, sustaining programmable peak stresses up to 16\u00a0MPa. CoDE exhibits reversible lock\u2013unlock states while fully preserving its peak stress, elastic modulus, and energy dissipation after repeated loading to 85% compressive strain. Cyclic compressive loading mechanically \u201ctrains\u201d the biopolymer hydrogel by altering its microstructure. Chemically triggering the release of stored elastic energy in the biopolymer network generates actuation forces. Further, CoDE is tested as a bio\u2010inspired, externally driven swimmer that can be subjected to large\u2010scale, repetitive deformation with predictable kinematics that match finite\u2010element simulations at the device level. The CoDE platform has future applications for building soft\u2010material machines for adaptive soft robotics, dynamic biointerfaces, and mechanically instructive biomaterials.<\/jats:p>","DOI":"10.1002\/advs.78047","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:21:01Z","timestamp":1791775261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sea Cucumber\u2010Inspired Double\u2010Network Biopolymer Hydrogels for Programmable Soft Machines"],"prefix":"10.1002","author":[{"given":"Luo","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and Applied Mechanics School of Engineering and Applied Science University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Applied Mechanics School of Engineering and Applied Science University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-907X","authenticated-orcid":false,"given":"Purohit","family":"Prashant K.","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Applied Mechanics School of Engineering and Applied Science University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-879X","authenticated-orcid":false,"given":"Vining","family":"Kyle H.","sequence":"additional","affiliation":[{"name":"Preventive and Restorative Sciences School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Materials Science and Engineering School of Engineering and Applied Science University of Pennsylvania  Philadelphia Pennsylvania 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