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Although immunotherapy offers a strategy to prevent recurrence, the role of tumor\u2010draining lymph nodes (TDLNs) in post\u2010ablation immune regulation remains underexplored. Here, single\u2010cell RNA sequencing (scRNA\u2010seq) reveals pronounced macrophage remodeling in TDLNs following incomplete MWA (iMWA), characterized by an increased representation of immunosuppressive\n                    <jats:italic>\n                      Folr2\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      Apoe\n                      <jats:sup>+<\/jats:sup>\n                    <\/jats:italic>\n                    macrophage subsets. These populations exhibit broad colony\u2010stimulating factor 1 receptor (\n                    <jats:italic>Csf1r<\/jats:italic>\n                    ) expression, accompanied by enhanced CSF signaling and macrophage\u2010centered intercellular communication, implicating CSF1R\u2010associated macrophage remodeling in post\u2010ablation immunosuppression. Accordingly, an albumin\u2010based lipoprotein nanosystem co\u2010encapsulating paclitaxel (PTX) and the CSF1R inhibitor BLZ945 (PTX\/BLZ945@Alb\u2010lip) was developed. Across multiple tumor models, PTX\/BLZ945@Alb\u2010lip enhances immunomodulator delivery to both TDLNs and tumors, remodels the macrophage\u2010mediated immunosuppressive microenvironment, and suppresses residual tumor growth after iMWA. Moreover, treatment promotes durable antitumor immune memory and protects cured mice against tumor rechallenge. These findings identify TDLNs as an important therapeutic site in post\u2010ablation immunotherapy and provide a potential strategy to prevent tumor recurrence following ablation.\n                  <\/jats:p>","DOI":"10.1002\/advs.78058","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:23:44Z","timestamp":1790655824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Macrophage\u2010Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2797-6486","authenticated-orcid":false,"given":"Xuexia","family":"Shan","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound Center of Minimally Invasive Treatment for Tumor Shanghai Tenth People's Hospital School of Medicine Tongji University  Shanghai P. R. 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