{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:00:57Z","timestamp":1790744457316,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370475"],"award-info":[{"award-number":["82370475"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070477"],"award-info":[{"award-number":["82070477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Abdominal aortic aneurysm (AAA) is a life\u2010threatening condition lacking effective pharmacological treatments, with emerging evidence highlighting the fundamental role of ferroptosis in its progression. Nuclear receptor coactivator 4 (NCOA4), known to mediate ferritinophagy and contribute to ferroptosis, is upregulated in macrophages from both angiotensin II (Ang II)\u2010induced murine AAA models and human AAA tissues. Global deletion of\n                    <jats:italic>Ncoa4<\/jats:italic>\n                    in mice suppressed Ang II\u2010induced AAA formation. Combined approaches using bone marrow transplantation and macrophage\u2010specific adeno\u2010associated virus (AAV) confirmed that\n                    <jats:italic>Ncoa4<\/jats:italic>\n                    knockdown in macrophages alleviates extracellular matrix (ECM) degeneration, inflammation, and vascular damage. Mechanistically, NCOA4 interacts with signal transducer and activator of transcription 1 (STAT1) to co\u2010activate the transcription of cholesterol 25\u2010hydroxylase (CH25H), an enzyme that catalyzes the production of 25\u2010hydroxycholesterol (25\u2010HC). Elevated 25\u2010HC levels were detected in the serum of both Ang II\u2010induced AAA mice and human AAA patients, and they promoted macrophage activation and ferroptosis, thereby driving AAA progression. Importantly, knockdown of\n                    <jats:italic>Ch25h<\/jats:italic>\n                    using lipid nanoparticle\u2010loaded microbubbles (LNP\/MBs) attenuated macrophage ferroptosis and AAA progression. These findings reveal a critical role of the NCOA4\/STAT1\/CH25H axis in AAA pathogenesis and offer promising biomarkers and therapeutic strategies for the disease.\n                  <\/jats:p>","DOI":"10.1002\/advs.78079","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:35:24Z","timestamp":1790742924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1\u2013CH25H Axis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3219-1994","authenticated-orcid":false,"given":"Zhinan","family":"Wu","sequence":"first","affiliation":[{"name":"Center Laboratory Punan Branch of Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of China"},{"name":"State Key Laboratory for Innovation and Transformation of Luobing 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