{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:40:23Z","timestamp":1792330823423,"version":"4.4.0"},"reference-count":93,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1101402"],"award-info":[{"award-number":["2021YFA1101402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1802600"],"award-info":[{"award-number":["2024YFA1802600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271428"],"award-info":[{"award-number":["82271428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301346"],"award-info":[{"award-number":["82301346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201540"],"award-info":[{"award-number":["82201540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The prevalence of autism spectrum disorder (ASD), a heterogeneous neurodevelopmental disorder with limited effective therapeutic drugs, has been rising worldwide. Missense mutations in Polybromo 1 (\n                    <jats:italic>Pbrm1<\/jats:italic>\n                    ), a core component of the SWI\/SNF (switch\/sucrose non\u2010fermentable) chromatin remodeling complex, have been identified as a risk factor for ASD; however, whether PBRM1 loss of function contributes to the pathogenesis remains elusive. Here we provide direct evidence that microglial PBRM1 deficiency leads to altered microglial clusters, excessive neurogenesis, and ASD\u2010like behaviors in mice. Integrated molecular analyses reveal that PBRM1 directly binds to the\n                    <jats:italic>Ccl5<\/jats:italic>\n                    promoter and represses the expression of CCL5. Elevated CCL5 promotes the proliferation and neuronal differentiation of neural stem\/progenitor cells (NSPCs) via the CCR1\/5\u2010\u03b2\u2010catenin signaling pathway. Importantly, pharmacological blockade of CCR1\/5 ameliorates behavioral deficits in\n                    <jats:italic>Pbrm1<\/jats:italic>\n                    cKO mice. Together, these findings identify a previously unrecognized microglia\u2013NSPC communication mechanism linking PBRM1 dysfunction to aberrant neurodevelopment and suggest the CCL5\u2013CCR1\/5 axis as a potential therapeutic target for ASD.\n                  <\/jats:p>","DOI":"10.1002\/advs.78086","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:45:20Z","timestamp":1792327520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism\u2010Like Behaviors via the CCL5\u2010CCR1\/5\u2010\u03b2\u2010catenin Signaling Axis"],"prefix":"10.1002","author":[{"given":"Yang\u2010Yang","family":"Duan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Fei","family":"Jiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Pei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hui","family":"Duan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7534-2462","authenticated-orcid":false,"given":"Xin\u2010Li","family":"Ouyang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Zhen","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7168-330X","authenticated-orcid":false,"given":"Sha","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Brain &amp; Disease Research VIB\u2010KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-065X","authenticated-orcid":false,"given":"Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology Innovation Center for Neurological Disorders Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-3381","authenticated-orcid":false,"given":"Zhao\u2010Qian","family":"Teng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2941-4667","authenticated-orcid":false,"given":"Chang\u2010Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Institute for Stem Cell and Regeneration Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1038\/s41380-023-02201-0","article-title":"Social Circuits And Their Dysfunction In Autism Spectrum Disorder","volume":"28","author":"Sato M.","year":"2023","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41593-018-0261-7","article-title":"Partial Loss of Psychiatric Risk Gene Mir137 in Mice Causes Repetitive Behavior And Impairs Sociability And Learning Via Increased Pde10a","volume":"21","author":"Cheng Y.","year":"2018","journal-title":"Nature Neuroscience"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/aur.239","article-title":"Global Prevalence Of Autism And Other Pervasive Developmental Disorders","volume":"5","author":"Elsabbagh M.","year":"2012","journal-title":"Autism Research"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.neubiorev.2011.10.008","article-title":"A Systematic Review And Meta\u2010Analysis of the fMRI Investigation Of Autism Spectrum Disorders","volume":"36","author":"Philip R. C. M.","year":"2012","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrg3585","article-title":"The Role of de novo Mutations In The Genetics Of Autism Spectrum Disorders","volume":"15","author":"Ronemus M.","year":"2014","journal-title":"Nature Reviews Genetics"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.neuron.2015.09.016","article-title":"Insights Into Autism Spectrum Disorder Genomic Architecture and Biology From 71 Risk Loci","volume":"87","author":"Sanders S. J.","year":"2015","journal-title":"Neuron"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrg.2017.4","article-title":"Autism Genetics: Opportunities And Challenges For Clinical Translation","volume":"18","author":"Vorstman J. A. S.","year":"2017","journal-title":"Nature Reviews Genetics"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.31887\/DCNS.2009.11.1\/jdbuxbaum","article-title":"Multiple Rare Variants In The Etiology Of Autism Spectrum Disorders","volume":"11","author":"Buxbaum J. D.","year":"2009","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature10989","article-title":"Sporadic Autism Exomes Reveal A Highly Interconnected Protein Network of de novo Mutations","volume":"485","author":"O'Roak B. J.","year":"2012","journal-title":"Nature"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ejhg.2011.24","article-title":"Reduced Transcript Expression Of Genes Affected By Inherited and de novo CNVs in Autism","volume":"19","author":"Nord A. S.","year":"2011","journal-title":"European Journal of Human Genetics"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11011","article-title":"Patterns and Rates Of Exonic de novo Mutations In Autism Spectrum Disorders","volume":"485","author":"Neale B. M.","year":"2012","journal-title":"Nature"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"10055","DOI":"10.1073\/pnas.1908238117","article-title":"Loss of the Neural\u2010Specific BAF Subunit ACTL6B Relieves Repression Of Early Response Genes And Causes Recessive Autism","volume":"117","author":"Wenderski W.","year":"2020","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/JCMA.0000000000001245","article-title":"Association of PBRM1 rs2251219 With Major Depressive Disorder And Biochemical Variables In A Taiwanese Cohort","volume":"88","author":"Chou K. J.","year":"2025","journal-title":"Journal of the Chinese Medical Association"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.xgen.2023.100471","article-title":"Multi\u2010Omics Integration Identifies Cell\u2010State\u2010Specific Repression by PBRM1\u2010PIAS1 Cooperation","volume":"4","author":"Ho P. J.","year":"2024","journal-title":"Cell Genomics"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.3390\/cells12121556","article-title":"PBAF Subunit Pbrm1 Selectively Influences the Transition From Progenitors to Pre\u2010Myelinating Cells During Oligodendrocyte Development","volume":"12","author":"Waldhauser V.","year":"2023","journal-title":"Cells\u2010Basel"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-neuro-110920-023056","article-title":"Microglia and Neurodevelopmental Disorders","volume":"45","author":"Lukens J. R.","year":"2022","journal-title":"Annual Review of Neuroscience"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.molmed.2019.08.013","article-title":"Microglia as Dynamic Cellular Mediators of Brain Function","volume":"25","author":"Wright\u2010Jin E. C.","year":"2019","journal-title":"Trends in Molecular Medicine"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417297","article-title":"Microglia Modulate Neurodevelopment in Autism Spectrum Disorder and Schizophrenia","volume":"24","author":"Fan G.","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1038\/s41467-020-15530-3","article-title":"Elevated Protein Synthesis In Microglia Causes Autism\u2010Like Synaptic And Behavioral Aberrations","volume":"11","author":"Xu Z.\u2010X.","year":"2020","journal-title":"Nature Communications"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.2174\/1570159X21666221220155455","article-title":"Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications","volume":"21","author":"Liu C.","year":"2023","journal-title":"Current Neuropharmacology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.tins.2021.08.005","article-title":"Hippocampal Contributions To Social And Cognitive Deficits In Autism Spectrum Disorder","volume":"44","author":"Banker S. M.","year":"2021","journal-title":"Trends in Neurosciences"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1016\/j.celrep.2017.11.050","article-title":"A Single\u2010Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche","volume":"21","author":"Artegiani B.","year":"2017","journal-title":"Cell Reports"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.cell.2020.12.032","article-title":"Changes in Genome Architecture And Transcriptional Dynamics Progress Independently Of Sensory Experience During Post\u2010Natal Brain Development","volume":"184","author":"Tan L.","year":"2021","journal-title":"Cell"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.stem.2022.09.010","article-title":"A Single\u2010Cell Transcriptome Atlas Of Glial Diversity In The Human Hippocampus Across The Postnatal Lifespan","volume":"29","author":"Su Y.","year":"2022","journal-title":"Cell Stem Cell"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.stem.2021.08.015","article-title":"Human Microglia States Are Conserved Across Experimental Models And Regulate Neural Stem Cell Responses In Chimeric Organoids","volume":"28","author":"Popova G.","year":"2021","journal-title":"Cell Stem Cell"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuron.2018.12.006","article-title":"Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single\u2010Cell RNA Sequencing","volume":"101","author":"Li Q.","year":"2019","journal-title":"Neuron"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41586-022-05056-7","article-title":"Pyramidal Neuron Subtype Diversity Governs Microglia States In The Neocortex","volume":"608","author":"Stogsdill J. A.","year":"2022","journal-title":"Nature"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.celrep.2020.01.010","article-title":"Microglia Heterogeneity in the Single\u2010Cell Era","volume":"30","author":"Masuda T.","year":"2020","journal-title":"Cell Reports"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1038\/s41467-022-31797-0","article-title":"Microglia Coordinate Cellular Interactions During Spinal Cord Repair In Mice","volume":"13","author":"Brennan F. H.","year":"2022","journal-title":"Nature Communications"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.stem.2022.02.004","article-title":"Decoding the Temporal And Regional Specification Of Microglia In The Developing Human Brain","volume":"29","author":"Li Y.","year":"2022","journal-title":"Cell Stem Cell"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad8670","article-title":"Microglia Development Follows A Stepwise Program To Regulate Brain Homeostasis","volume":"353","author":"Matcovitch\u2010Natan O.","year":"2016","journal-title":"Science"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1038\/s41467-019-13608-1","article-title":"PBRM1 Acts as a p53 Lysine\u2010Acetylation Reader To Suppress Renal Tumor Growth","volume":"10","author":"Cai W.","year":"2019","journal-title":"Nature Communications"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/1878-0261.12434","article-title":"High Affinity Binding of H3K14ac Through Collaboration Of Bromodomains 2, 4 and 5 is Critical For The Molecular And Tumor Suppressor Functions of PBRM1","volume":"13","author":"Liao L.","year":"2019","journal-title":"Molecular Oncology"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.immuni.2024.05.008","article-title":"Collaboration Between Distinct SWI\/SNF Chromatin Remodeling Complexes Directs Enhancer Selection And Activation Of Macrophage Inflammatory Genes","volume":"57","author":"Liao J.","year":"2024","journal-title":"Immunity"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-022-04658-5","article-title":"Structure of Human Chromatin\u2010Remodelling PBAF Complex Bound To A Nucleosome","volume":"605","author":"Yuan J.","year":"2022","journal-title":"Nature"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.3390\/cancers12071765","article-title":"The CCL5\/CCR5 Axis in Cancer Progression","volume":"12","author":"Aldinucci D.","year":"2020","journal-title":"Cancers"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/hep.32458","article-title":"C\u2010C Motif Chemokine Ligand 5 Confines Liver Regeneration By Down\u2010Regulating Reparative Macrophage\u2010Derived Hepatocyte Growth Factor In A Forkhead Box O 3a\u2013Dependent Manner","volume":"76","author":"Huang M.","year":"2022","journal-title":"Hepatology"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.neuron.2023.04.006","article-title":"Microglial\u2010to\u2010Neuronal CCR5 Signaling Regulates Autophagy In Neurodegeneration","volume":"111","author":"Festa B. P.","year":"2023","journal-title":"Neuron"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.3390\/ijms25073788","article-title":"CC Chemokine Family Members\u2032 Modulation as a Novel Approach for Treating Central Nervous System and Peripheral Nervous System Injury\u2014A Review of Clinical and Experimental Findings","volume":"25","author":"Ciechanowska A.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00018-018-2988-4","article-title":"The Contribution of Environmental Exposure To The Etiology Of Autism Spectrum Disorder","volume":"76","author":"Bolte S.","year":"2019","journal-title":"Cellular and Molecular Life Sciences"},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1001\/jamapsychiatry.2019.1411","article-title":"Association of Genetic and Environmental Factors With Autism in a 5\u2010Country Cohort","volume":"76","author":"Bai D.","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41398-020-0708-y","article-title":"Novel Genetic Susceptibility Loci Identified By Family Based Whole Exome Sequencing In Han Chinese Schizophrenia Patients","volume":"10","author":"Li M.","year":"2020","journal-title":"Translational Psychiatry"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1074\/jbc.M116.746875","article-title":"Individual Bromodomains of Polybromo\u20101 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma","volume":"292","author":"Porter E. G.","year":"2017","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"e_1_2_10_45_1","first-page":"1595","article-title":"Microglia Homeostasis Mediated by Epigenetic ARID1A Regulates Neural Progenitor Cells Response And Leads To Autism\u2010Like Behaviors","volume":"29","author":"Su L. B.","year":"2022","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb9888","article-title":"IL4\u2010Driven Microglia Modulate Stress Resilience Through BDNF\u2010Dependent Neurogenesis","volume":"7","author":"Zhang J.","year":"2021","journal-title":"Science Advances"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"RC216","DOI":"10.1523\/JNEUROSCI.22-07-j0001.2002","article-title":"Neurodegenerative and Neuroprotective Effects Of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2","volume":"22","author":"Fontaine V.","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1001\/jama.2011.1638","article-title":"Neuron Number And Size In Prefrontal Cortex Of Children With Autism","volume":"306","author":"Courchesne E.","year":"2011","journal-title":"Jama"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1038\/s41380-022-01563-1","article-title":"Dormant State Of Quiescent Neural Stem Cells Links Shank3 Mutation To Autism Development","volume":"27","author":"Kim H.","year":"2022","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.eurpsy.2013.02.005","article-title":"The Neurobiology of Autism Spectrum Disorders","volume":"29","author":"Parellada M.","year":"2014","journal-title":"European Psychiatry"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fncel.2017.00359","article-title":"Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity","volume":"11","author":"Gilbert J.","year":"2017","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.2174\/1570159X21666221220155455","article-title":"Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications","volume":"21","author":"Liu C.","year":"2023","journal-title":"Current Neuropharmacology"},{"key":"e_1_2_10_53_1","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1038\/s41380-024-02441-8","article-title":"Molecular Profiling Of The Hippocampus Of Children With Autism Spectrum Disorder","volume":"29","author":"Rexrode L. E.","year":"2024","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_10_54_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41398-021-01223-y","article-title":"Cntn4, A Risk Gene For Neuropsychiatric Disorders, Modulates Hippocampal Synaptic Plasticity And Behavior","volume":"11","author":"Oguro\u2010Ando A.","year":"2021","journal-title":"Translational Psychiatry"},{"key":"e_1_2_10_55_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2026.106547","article-title":"Comorbidity Of Autism Spectrum Disorders And Anxiety Disorders: Insights From Neuronal Circuitry Studies","volume":"182","author":"Webster J. F.","year":"2026","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"e_1_2_10_56_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI174194","article-title":"Stromal Pbrm1 Mediates Chromatin Remodeling Necessary For Embryo Implantation In The Mouse Uterus","volume":"134","author":"Xin Q. L.","year":"2024","journal-title":"Journal of Clinical Investigation"},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrc3068","article-title":"SWI\/SNF Nucleosome Remodellers and Cancer","volume":"11","author":"Wilson B. G.","year":"2011","journal-title":"Nature Reviews Cancer"},{"key":"e_1_2_10_58_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41556-023-01122-y","article-title":"PBRM1\u2010Deficient PBAF Complexes Target Aberrant Genomic Loci To Activate the NF\u2010\u03baB Pathway In Clear Cell Renal Cell Carcinoma","volume":"25","author":"Yao X.","year":"2023","journal-title":"Nature Cell Biology"},{"key":"e_1_2_10_59_1","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/s41467-020-15959-6","article-title":"PBRM1 Loss Defines A Nonimmunogenic Tumor Phenotype Associated With Checkpoint Inhibitor Resistance In Renal Carcinoma","volume":"11","author":"Liu X.\u2010D.","year":"2020","journal-title":"Nature Communications"},{"key":"e_1_2_10_60_1","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2029298","article-title":"MUC1\u2010C Integrates Type II Interferon And Chromatin Remodeling Pathways In Immunosuppression Of Prostate Cancer","volume":"11","author":"Hagiwara M.","year":"2022","journal-title":"Oncoimmunology"},{"key":"e_1_2_10_61_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.aao1710","article-title":"A Major Chromatin Regulator Determines Resistance Of Tumor Cells to T Cell\u2013Mediated Killing","volume":"359","author":"Pan D.","year":"2018","journal-title":"Science"},{"key":"e_1_2_10_62_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2172-13-9","article-title":"IL\u201010 Transcription Is Negatively Regulated by BAF180, a Component of the SWI\/SNF Chromatin Remodeling Enzyme","volume":"13","author":"Wurster A. L.","year":"2012","journal-title":"BMC Immunology"},{"key":"e_1_2_10_63_1","doi-asserted-by":"crossref","DOI":"10.1080\/23723556.2020.1729680","article-title":"PBRM1 Suppresses Tumor Growth As A Novel p53 Acetylation Reader","volume":"7","author":"Cai W.","year":"2020","journal-title":"Molecular & Cellular Oncology"},{"key":"e_1_2_10_64_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.818518","article-title":"mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Implicated in the Pathogenesis of Autism Spectrum Disorder","volume":"13","author":"Wang B.","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_10_65_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.9758\/cpn.2022.20.1.109","article-title":"Increased Serum Level of CCL5 in Children With Attention\u2011Deficit\/Hyperactivity Disorder: First Results About Serum Chemokines","volume":"20","author":"Ozaslan A.","year":"2022","journal-title":"Clinical Psychopharmacology and Neuroscience"},{"key":"e_1_2_10_66_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrn3978","article-title":"Immune Mediators in the Brain And Peripheral Tissues In Autism Spectrum Disorder","volume":"16","author":"Estes M. L.","year":"2015","journal-title":"Nature Reviews Neuroscience"},{"key":"e_1_2_10_67_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1250685","article-title":"CCL5 Promotes LFA\u20101 Expression in Th17 Cells And Induces LCK and ZAP70 Activation In A Mouse Model of Parkinson's Disease","volume":"15","author":"Zhao J.","year":"2023","journal-title":"Frontiers in Aging Neuroscience"},{"key":"e_1_2_10_68_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fnana.2017.00137","article-title":"Glial\u2010 and Neuronal\u2010Specific Expression of CCL5 mRNA in the Rat Brain","volume":"11","author":"Lanfranco M. F.","year":"2017","journal-title":"Frontiers in Neuroanatomy"},{"key":"e_1_2_10_69_1","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1038\/s41380-021-01103-3","article-title":"CCL5 Promotion Of Bioenergy Metabolism Is Crucial For Hippocampal Synapse Complex And Memory Formation","volume":"26","author":"Ajoy R.","year":"2021","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_10_70_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12929-024-01083-w","article-title":"CCL5 is Essential for Axonogenesis And Neuronal Restoration After Brain Injury","volume":"31","author":"Ho M.\u2010H.","year":"2024","journal-title":"Journal of Biomedical Science"},{"key":"e_1_2_10_71_1","doi-asserted-by":"crossref","unstructured":"S.Wegener A.Buschler A. V.Stempel et\u00a0al. \u201cDefective Synapse Maturation and Enhanced Synaptic Plasticity in Shank2 Deltaex7(\u2010\/\u2010) Mice \u201deNeuro5(2018): 0398\u201017.","DOI":"10.1523\/ENEURO.0398-17.2018"},{"key":"e_1_2_10_72_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2015.01.011","article-title":"Dendritic Spine Dysgenesis In Autism Related Disorders","volume":"601","author":"Phillips M.","year":"2015","journal-title":"Neuroscience Letters"},{"key":"e_1_2_10_73_1","doi-asserted-by":"crossref","unstructured":"R. T.Ash J.Park B.Suter H. Y.Zoghbi andS. M.Smirnakis \u201cExcessive Formation and Stabilization of Dendritic Spine Clusters in the MECP2\u2010Duplication Syndrome Mouse Model of Autism \u201deNeuro8(2021): 0282\u201020.","DOI":"10.1523\/ENEURO.0282-20.2020"},{"key":"e_1_2_10_74_1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.cell.2020.07.008","article-title":"ATP Synthase c\u2010Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome","volume":"182","author":"Licznerski P.","year":"2020","journal-title":"Cell"},{"key":"e_1_2_10_75_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12974-026-03714-5","article-title":"Astrocytic CCL5 Orchestrates CCR5\u2010Positive Neuronal Necroptosis In Subarachnoid Hemorrhage","volume":"23","author":"Chen P.","year":"2026","journal-title":"Journal of Neuroinflammation"},{"key":"e_1_2_10_76_1","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.3390\/ijms25084337","article-title":"Novel Findings on CCR1 Receptor in CNS Disorders: A Pathogenic Marker Useful in Controlling Neuroimmune and Neuroinflammatory Mechanisms in Parkinson's Disease","volume":"25","author":"Repici A.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_10_77_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adt5859","article-title":"Galectin\u20103 Induces Neurodevelopmental Apical\u2010Basal Polarity And Regulates Gyrification","volume":"11","author":"Soares L. C.","year":"2025","journal-title":"Science Advances"},{"key":"e_1_2_10_78_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.3390\/biom10050798","article-title":"Galectin\u20103: Roles in Neurodevelopment, Neuroinflammation, and Behavior","volume":"10","author":"Srejovic I.","year":"2020","journal-title":"Biomolecules"},{"key":"e_1_2_10_79_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.expneurol.2007.06.024","article-title":"Galectin\u20101 Regulates Neurogenesis In The Subventricular Zone And Promotes Functional Recovery After Stroke","volume":"207","author":"Ishibashi S.","year":"2007","journal-title":"Experimental Neurology"},{"key":"e_1_2_10_80_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41419-019-1596-z","article-title":"ALK5 Signaling Pathway Mediates Neurogenesis And Functional Recovery After Cerebral Ischemia\/Reperfusion In Rats via Gadd45b","volume":"10","author":"Zhang K.","year":"2019","journal-title":"Cell Death & Disease"},{"key":"e_1_2_10_81_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/cne.10964","article-title":"Neural Stem And Progenitor Cells In Nestin\u2010GFP Transgenic Mice","volume":"469","author":"Mignone J. L.","year":"2004","journal-title":"Journal of Comparative Neurology"},{"key":"e_1_2_10_82_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex Genome Engineering Using CRISPR\/Cas Systems","volume":"339","author":"Cong L.","year":"2013","journal-title":"Science"},{"key":"e_1_2_10_83_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s13287-022-03216-0","article-title":"KW\u20102449 and VPA Exert Therapeutic Effects On Human Neurons And Cerebral Organoids Derived From MECP2\u2010Null hESCs","volume":"13","author":"Xu Y.\u2010J.","year":"2022","journal-title":"Stem Cell Research & Therapy"},{"key":"e_1_2_10_84_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1186\/s12964-024-01852-y","article-title":"Loss of Microglial Arid1a Exacerbates Microglial Scar Formation Via Elevated CCL5 After Traumatic Brain Injury","volume":"22","author":"Ke J.\u2010P.","year":"2024","journal-title":"Cell Communication and Signaling"},{"key":"e_1_2_10_85_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.stem.2010.02.017","article-title":"Epigenetic Regulation of miR\u2010184 by MBD1 Governs Neural Stem Cell Proliferation And Differentiation","volume":"6","author":"Liu C.","year":"2010","journal-title":"Cell Stem Cell"},{"key":"e_1_2_10_86_1","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41418-023-01199-w","article-title":"Abnormal Chromatin Remodeling Caused by ARID1A Deletion Leads To Malformation Of The Dentate Gyrus","volume":"30","author":"Liu P.\u2010P.","year":"2023","journal-title":"Cell Death & Differentiation"},{"key":"e_1_2_10_87_1","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1038\/s41380-021-01122-0","article-title":"Role of Adult Hippocampal Neurogenesis In The Antidepressant Actions Of Lactate","volume":"26","author":"Carrard A.","year":"2021","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_10_88_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.stem.2019.09.009","article-title":"Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis","volume":"25","author":"Wang J.","year":"2019","journal-title":"Cell Stem Cell"},{"key":"e_1_2_10_89_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing Adult Hippocampal Neurogenesis Is Sufficient To Improve Pattern Separation","volume":"472","author":"Sahay A.","year":"2011","journal-title":"Nature"},{"key":"e_1_2_10_90_1","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13314","article-title":"Abnormal Microglial Polarization Induced by Arid1a Deletion Leads To Neuronal Differentiation Deficits","volume":"55","author":"Gong M.","year":"2022","journal-title":"Cell Proliferation"},{"key":"e_1_2_10_91_1","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1038\/s41596-020-0382-9","article-title":"A Standardized Social Preference Protocol For Measuring Social Deficits In Mouse Models Of Autism","volume":"15","author":"Rein B.","year":"2020","journal-title":"Nature Protocols"},{"key":"e_1_2_10_92_1","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated Analysis Of Multimodal Single\u2010Cell Data","volume":"184","author":"Hao Y.","year":"2021","journal-title":"Cell"},{"key":"e_1_2_10_93_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The Dynamics And Regulators Of Cell Fate Decisions Are Revealed By Pseudotemporal Ordering Of Single Cells","volume":"32","author":"Trapnell C.","year":"2014","journal-title":"Nature Biotechnology"},{"key":"e_1_2_10_94_1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and Analysis of Cell\u2010Cell Communication Using CellChat","volume":"12","author":"Jin S.","year":"2021","journal-title":"Nature Communications"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.78086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:45:31Z","timestamp":1792327531000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":93,"alternative-id":["10.1002\/advs.78086"],"URL":"https:\/\/doi.org\/10.1002\/advs.78086","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]},"assertion":[{"value":"2026-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e78086"}}