{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:58:24Z","timestamp":1790787504556,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572688"],"award-info":[{"award-number":["82572688"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tumor\u2010derived exosomes (tExos) are promising biomarkers for early pancreatic cancer (PC) diagnosis, yet current detection methods are limited by cumbersome implementation, high sample consumption, and complex matrix interference. Herein, we developed immunomagnetic\u2010MXene bifunctional probes coupled with terahertz (THz) metamaterials to synergistically increase the sensitivity and specificity of PC\u2010derived tExos detection. Antibodies against ZIP4 and glypican\u20101 (GPC\u20101) were separately conjugated to magnetic beads (MBs) and MXene nanosheets, which yielded two probes that simultaneously targeted PC\u2010derived tExos, enabling highly specific sandwich\u2010type capture of target exosomes. Moreover, MXene increased the tExo\u2010induced THz metamaterial resonance and outperformed AuNPs in signal amplification, endowing the method with a limit of detection (LOD) of 647 particles mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The developed THz metasensor achieved accurate detection of early tumor formation and evaluation of therapeutic responses in PC mouse models. In a 60\u2010subject clinical cohort, it distinguished all\u2010stage PC patients from healthy controls with an area under the curve (AUC) of 0.997. Compared with that of the conventional CA19\u20109 assay, our THz metasensor demonstrated superior diagnostic accuracy in 11 early\u2010stage PC patients (AUC: 0.991\u00a0vs. 0.809), with a simplified workflow, minimal sample requirement (10\u00a0\u00b5L), and low cost (&lt; $5), highlighting its potential for clinical translation in early PC diagnosis.\n                  <\/jats:p>","DOI":"10.1002\/advs.78093","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:57:57Z","timestamp":1790783877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunomagnetic\u2010MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor\u2010Derived Exosomes"],"prefix":"10.1002","author":[{"given":"Weidong","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Laser and Optoelectronics School of Precision Instrument and Optoelectronics Engineering Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Southwest Hospital Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechen","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Laboratory 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