{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:51:51Z","timestamp":1791355911591,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62635004\uff1a82273025"],"award-info":[{"award-number":["62635004\uff1a82273025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Intermittent fasting (IF) exerts antitumor activity in colorectal cancer (CRC), but the tumor\u2010intrinsic metabolic mechanism linking nutrient restriction to antitumor immunity remains unclear. In this study, IF reduced taurine availability and suppressed tumor growth in a CD\n                    <jats:sup>8+<\/jats:sup>\n                    T cell\u2010dependent manner. Taurine supplementation attenuated this effect, whereas pharmacological inhibition of taurine uptake partially recapitulated fasting\u2010associated tumor suppression in preclinical models. Mechanistically, taurine is associated with the endoplasmic reticulum chaperone GRP78 and contributes to the maintenance of PERK abundance under nutrient stress. As a metabolic consequence of IF, taurine restriction impaired PERK stability, suppressed downstream ERO1A signaling, and redirected CRC cells from stress tolerance toward paraptosis\u2010like immunogenic stress. PERK loss enhanced CD\n                    <jats:sup>8+<\/jats:sup>\n                    T\u2010cell activation, remodeled the tumor microenvironment toward a less suppressive state, and supported tumor control in combination with anti\u2010PD\u20101 therapy. The present study identified taurine restriction as a functional metabolic feature of IF that compromises PERK\u2010dependent stress adaptation and promotes antitumor immunity in CRC.\n                  <\/jats:p>","DOI":"10.1002\/advs.78107","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:17:17Z","timestamp":1791353837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation\u2010Associated Paraptosis\u2010Like Cell Death in Colorectal Cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-9253","authenticated-orcid":false,"given":"Baohui","family":"Song","sequence":"first","affiliation":[{"name":"Endoscopy Center Zhongshan Hospital Fudan University Shanghai Digestive Endoscopy Diagnosis and Treatment Engineering Technology Research Center  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