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Conventional hydrogel dressings, however, typically lack both the spatiotemporal precision and synergistic multifunctionality that are required to counteract the complex pathological drivers of diabetic wound chronicity. Here, we present a biomimetic nanocomposite hydrogel (QN\u2010S\u2010HG) that integrates neutrophil\u2010membrane\u2010coated quercetin\u2010loaded nanoparticles with a pH\u2010responsive hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) releasing hyaluronic acid network. The neutrophil\u2010mimetic nanoparticles achieve dual\u2010targeted delivery to inflammatory cells and bacteria, simultaneously exerting anti\u2010inflammatory, antioxidant, and broad\u2010spectrum antibacterial effects. Concurrently, the H\n                    <jats:sub>2<\/jats:sub>\n                    S donor S\u2010propargylcysteine (SPRC) is covalently conjugated via dynamic Schiff base bonds to the hydrogel scaffold, enabling acid\u2010triggered release in the pathological wound milieu to stimulate angiogenesis. Remarkably, the crosslinker\u2010free and hydrogen\u2010bond\u2010mediated hyaluronic acid network endows the hydrogel with injectability, self\u2010healing, and tissue\u2010adhesive properties, ensuring conformal coverage and sustained local bioactivity. In a diabetic rat full\u2010thickness wound model, QN\u2010S\u2010HG markedly accelerates closure, promotes macrophage repolarization, enhances neovascularization, and facilitates orderly collagen remodeling with hair follicle regeneration. By orchestrating targeted pharmacotherapy, microenvironment\u2010triggered gaseous signaling, and adaptive material mechanics, this platform addresses the multifaceted pathophysiology of diabetic wounds and offers a clinically translatable paradigm for advanced regenerative wound care.\n                  <\/jats:p>","DOI":"10.1002\/advs.78108","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:33:23Z","timestamp":1791351203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual\u2010Targeting and On\u2010Demand H\n                    <sub>2<\/sub>\n                    S Gasotransmission for Multifactorial Diabetic Wound Therapy"],"prefix":"10.1002","author":[{"given":"Kefan","family":"Wu","sequence":"first","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Mechanism and Quality of Chinese Medicine Macau University of Science and Technology  Taipa Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Mechanism and Quality of Chinese Medicine Macau University of Science and Technology  Taipa Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Mechanism and Quality of Chinese Medicine Macau University of Science and Technology  Taipa Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Mechanism and Quality of Chinese Medicine Macau University of Science and Technology  Taipa Macao 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