{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:52:22Z","timestamp":1791132742031,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500352"],"award-info":[{"award-number":["82500352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0801403"],"award-info":[{"award-number":["2019YFA0801403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010515"],"award-info":[{"award-number":["2023A1515010515"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013264"],"award-info":[{"award-number":["2024A1515013264"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M781431"],"award-info":[{"award-number":["2025M781431"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Successful pregnancy requires dynamic extracellular matrix (ECM) remodeling at the maternal\u2010fetal interface, yet whether individual collagen subtypes actively regulate this process remains unknown. Here, collagen type XXIV alpha 1 chain (COL24A1), a uterine\u2010enriched fibrillar collagen, is identified as a regulator of pregnancy\u2010associated ECM\u2010immune homeostasis.\n                    <jats:italic>Col24a1<\/jats:italic>\n                    \u2010deficient mice exhibit increased embryo resorption, fetal growth impairment, and pregnancy\u2010dependent uterine collagen accumulation and inflammation. Mechanistically,\n                    <jats:italic>Col24a1<\/jats:italic>\n                    loss promotes expansion of a maladaptive\n                    <jats:italic>Timp1<\/jats:italic>\n                    \u2010high stromal state, accompanied by reduced matrix metalloproteinase 2 activity, impaired ECM degradation, and altered stromal\u2010immune communication and inflammatory immune\u2010cell states.\n                    <jats:italic>COL24A1<\/jats:italic>\n                    silencing in human endometrial stromal cells similarly impairs decidualization and increases\n                    <jats:italic>TIMP1<\/jats:italic>\n                    and fibrillar collagen gene expression. Hydroxychloroquine partially rescues embryo resorption and attenuates uterine inflammation, indicating that these pregnancy\u2010associated abnormalities are pharmacologically modifiable. Moreover, a patient with 12 consecutive unexplained early pregnancy losses carrying rare heterozygous\n                    <jats:italic>COL24A1<\/jats:italic>\n                    variants shows a concordant decidual phenotype with reduced COL24A1 and increased TIMP1, inflammation, and collagen deposition. These findings identify\n                    <jats:italic>COL24A1<\/jats:italic>\n                    as a collagen subtype\u2010specific regulator of maternal\u2010fetal ECM\u2010immune homeostasis and nominate it as a candidate susceptibility gene for unexplained recurrent pregnancy loss.\n                  <\/jats:p>","DOI":"10.1002\/advs.78110","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:06:37Z","timestamp":1791129997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Control of Stromal\u2010Immune Coupling by\n                    <i>COL24A1<\/i>\n                    Underlies Pregnancy Maintenance"],"prefix":"10.1002","author":[{"given":"Teng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-950X","authenticated-orcid":false,"given":"Wenyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjie","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 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Gynecology &amp; Obstetrics Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong Clinical Research Academy of Chinese Medicine  Guangzhou China"},{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qionglan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010Sen University  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