{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:45:27Z","timestamp":1792331127706,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400241"],"award-info":[{"award-number":["82400241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inflammatory bowel disease (IBD) in older individuals is characterized by immune senescence and deteriorating intestinal homeostasis, both of which limit the efficacy of current therapies. Here, we develop fluorinated \u03b2\u2010glucan\/pectin nanogels (F\n                    <jats:sub>2<\/jats:sub>\n                    \u2010Ast@NGs) for oral delivery of astilbin, a natural flavonoid with anti\u2010inflammatory and immunoregulatory activities. This multifunctional platform integrates gastrointestinal protection, colon\u2010targeted release, and local immune modulation. The \u03b2\u2010glucan shell preserves nanogel stability during upper gastrointestinal transit while enabling \u03b2\u2010glucanase\u2010responsive disassembly in the colon. Fluorocarbon segments enhance mucus penetration, and the pectin matrix prolongs colonic retention, promoting drug accumulation at inflamed sites. In aged mice with dextran sulfate sodium (DSS)\u2010induced colitis, F\n                    <jats:sub>2<\/jats:sub>\n                    \u2010Ast@NGs alleviate disease severity, attenuate senescence\u2010associated features of colonic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, and enhance Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cell (T\n                    <jats:sub>reg<\/jats:sub>\n                    ) responses. Concurrently, the \u03b2\u2010glucan\/pectin nanogel matrix contributes to increased short\u2010chain fatty acid production and favorable alterations in gut microbial composition. Notably, the therapeutic efficacy of F\n                    <jats:sub>2<\/jats:sub>\n                    \u2010Ast@NGs is markedly attenuated in Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>reg<\/jats:sub>\n                    \u2010depleted mice, supporting an important role for T\n                    <jats:sub>reg<\/jats:sub>\n                    \u2010mediated immunoregulation. Collectively, F\n                    <jats:sub>2<\/jats:sub>\n                    \u2010Ast@NGs enable precise colonic delivery while coordinately remodeling the intestinal immune and microbial microenvironment, providing a promising oral nanotherapeutic strategy for colitis in aged hosts.\n                  <\/jats:p>","DOI":"10.1002\/advs.78123","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:11:17Z","timestamp":1792329077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Astilbin Nanogels Modulate Senescence\u2010Associated CD4\n                    <sup>+<\/sup>\n                    T Cells and Promote T\n                    <sub>reg<\/sub>\n                    Induction in Aged Mice with Colitis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-1355","authenticated-orcid":false,"given":"Lei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Fourth Affiliated Hospital of Soochow University College of Pharmaceutical Sciences Medical Center of Soochow University  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Soochow University Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1039-9801","authenticated-orcid":false,"given":"Qian","family":"Ren","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center of Suzhou Medical College Soochow University Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Fourth Affiliated Hospital of Soochow University College of Pharmaceutical Sciences Medical Center of Soochow University  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Hospital of Qingdao University Qingdao University Qingdao Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongshen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong Second Medical University Weifang Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocheng","family":"Du","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Shandong Second Medical University Weifang Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Fourth Affiliated Hospital of Soochow University College of Pharmaceutical Sciences Medical Center of Soochow University  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peigen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Fourth Affiliated Hospital of Soochow University College of Pharmaceutical Sciences Medical Center of Soochow University  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7316-0430","authenticated-orcid":false,"given":"Jiangyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Fourth Affiliated Hospital of Soochow University College of Pharmaceutical Sciences Medical Center of Soochow University  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4372-2826","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Fourth Affiliated Hospital of Soochow University College of Pharmaceutical Sciences Medical Center of Soochow University  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-1266","authenticated-orcid":false,"given":"Jingjing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Fourth Affiliated Hospital of Soochow University College of Pharmaceutical Sciences Medical Center of Soochow University  Suzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010024\u201001035\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008940\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010025\u201001063\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)32448\u20100"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.08.011"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010022\u201000605\u2010x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010021119\u2010034359"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(22)00358\u20102"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522\u2010025\u201000677\u2010y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100938"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.08.060"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.07.032"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100180\u20101"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adv0985"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjad212.0124"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104202"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007251\u20100"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010020\u20100332\u20107"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908805106"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.11.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010024\u201001383\u20109"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116364"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo00727k"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2065661"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110450"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108035"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.12.035"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.07.016"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.848957"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514594"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00563"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.08.056"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106941.2008.00478.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.05.002"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2020.04.028"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxae056"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.108"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010021\u201000505\u20105"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402579"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100205\u2010x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.02.028"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010023\u201000890\u2010w"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910139106"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2433717100"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010024\u201001014\u20108"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2024217"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01248\u201021"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155385"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130959"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665\u20109913(19)30068\u20102"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.05.005"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00830"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13040815"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010025\u201000321\u20106"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000825\u2010x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201070898\u2010y"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401227"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.78123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:11:18Z","timestamp":1792329078000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":60,"alternative-id":["10.1002\/advs.78123"],"URL":"https:\/\/doi.org\/10.1002\/advs.78123","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]},"assertion":[{"value":"2026-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e78123"}}