{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:51:28Z","timestamp":1791352288707,"version":"4.3.1"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32671086"],"award-info":[{"award-number":["32671086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Induced pluripotent stem cell (iPSC) reprogramming and embryonic stem cell (ESC) differentiation represent opposite models of cell identity transition, yet their regulatory mechanisms remain incompletely understood. Here, we identify the Super Elongation Complex (SEC), the most pivotal regulators of transcription pause release, as a central driver of cell identity transition in both models.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : SEC depletion markedly impairs iPSC reprogramming efficiency, particularly during the early stage, by suppressing core reprogramming genes, including Klf4 and Myc, thereby disrupting key reprogramming events, such as cell\u2010cycle progression and activation of the pluripotency network. Mechanistically, SEC activates the expression of Klf4 and Myc by promoting the release of pre\u2010established paused RNA polymerase II (RNA Pol II). Moreover, SEC also cooperates with METTL3 to facilitate N6\u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) deposition and transcription pause release at Klf4 and Myc, revealing an additional regulatory layer during iPSC reprogramming. Similarly, during ESC neural induction, SEC upregulates neural gene expression and facilitates ESC transition into the neuroectoderm lineage, via promoting transcription pause release at relevant loci.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : These findings establish SEC as a shared regulator of cell identity transition in both iPSC reprogramming and ESC differentiation. Elucidating the mechanisms by which SEC drives cell identity transitions provides a foundation for further investigation into diverse cell identity transitions under physiological and pathological conditions.\n                  <\/jats:p>","DOI":"10.1002\/advs.78131","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:43:11Z","timestamp":1791351791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SEC Mediates m\n                    <sup>6<\/sup>\n                    A Deposition and Transcription Pause Release to Drive Cell Identity Transition"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-8414","authenticated-orcid":false,"given":"Zhijing","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province Northeast Agricultural University  Harbin Heilongjiang China"},{"name":"Department of Histology and Embryology School of Basic Medical Sciences Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology School of Basic Medical Sciences Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology School of Basic Medical Sciences Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1491-5417","authenticated-orcid":false,"given":"Yitong","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology School of Basic Medical Sciences Harbin Medical University  Harbin Heilongjiang 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Medical Sciences Harbin Medical University  Harbin Heilongjiang China"},{"name":"Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China (Harbin Medical University) Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.053"},{"issue":"7","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41580-022-00472-z","article-title":"Interplay Between Mechanics and Signalling in Regulating Cell Fate","volume":"23","author":"De Belly H.","year":"2022","journal-title":"Nature Reviews Molecular Cell 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