{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:52:17Z","timestamp":1791132737637,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472879"],"award-info":[{"award-number":["32472879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Epigenetic mechanisms underlying lactation traits in sheep remain poorly understood. Here, we systematically characterized the transcriptomic dynamics, chromatin accessibility landscape, and histone modification profiles of mammary gland tissues from Yuansheng Aite dairy sheep with divergent lactation performance. The lactalbumin alpha (\n                    <jats:italic>LALBA<\/jats:italic>\n                    ) locus harbors a super\u2010enhancer, and expression of\n                    <jats:italic>LALBA<\/jats:italic>\n                    was upregulated in sheep with low lactation performance. Enhancer E4 functions as the core active element within the\n                    <jats:italic>LALBA<\/jats:italic>\n                    super\u2010enhancer, and its repression reduced\n                    <jats:italic>LALBA<\/jats:italic>\n                    expression. Chromosome conformation capture\u2010polymerase chain reaction (3C\u2010PCR) confirmed a direct chromatin interaction between E4 and the\n                    <jats:italic>LALBA<\/jats:italic>\n                    promoter. The E74\u2010like ETS transcription factor 5 (ELF5) binds to both E4 and the\n                    <jats:italic>LALBA<\/jats:italic>\n                    promoter, consistent with the observation that E4 and the\n                    <jats:italic>LALBA<\/jats:italic>\n                    promoter region exhibit greater chromatin accessibility in the low lactation ewes. E4 promotes\n                    <jats:italic>LALBA<\/jats:italic>\n                    transcription via ELF5\u2010mediated chromatin looping, thereby inhibiting cell cycle progression and the proliferation of ovine mammary epithelial cells (OMECs). This study suggests a new target and provides a theoretical basis for the genetic improvement of lactation performance in sheep.\n                  <\/jats:p>","DOI":"10.1002\/advs.78138","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:08:58Z","timestamp":1791130138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ELF5\u2010Mediated Enhancer\u2013Promoter Interaction Regulates\n                    <i>LALBA<\/i>\n                    Expression in Ovine Mammary Gland"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-5215","authenticated-orcid":false,"given":"Xinmiao","family":"Wu","sequence":"first","affiliation":[{"name":"Gansu Engineering Lab of Genetic Improvement in Ruminants, College of Animal Science and Technology Gansu Agricultural University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-0085","authenticated-orcid":false,"given":"Jiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Gansu Engineering Lab of Genetic Improvement in Ruminants, College of Animal Science and Technology Gansu Agricultural University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Hao","sequence":"additional","affiliation":[{"name":"Gansu Engineering Lab of Genetic Improvement in Ruminants, College of Animal Science and Technology Gansu Agricultural University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingna","family":"Li","sequence":"additional","affiliation":[{"name":"Gansu Engineering Lab of Genetic Improvement in Ruminants, College of Animal Science and Technology Gansu Agricultural University  Lanzhou 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Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Ren","sequence":"additional","affiliation":[{"name":"Gansu Engineering Lab of Genetic Improvement in Ruminants, College of Animal Science and Technology Gansu Agricultural University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Gansu Engineering Lab of Genetic Improvement in Ruminants, College of Animal Science and Technology Gansu Agricultural University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixiong","family":"Hu","sequence":"additional","affiliation":[{"name":"Gansu Engineering Lab of Genetic Improvement in Ruminants, College of Animal Science and Technology Gansu Agricultural University  Lanzhou 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