{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:59Z","timestamp":1791352259913,"version":"4.3.1"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302646 82402836 82272432"],"award-info":[{"award-number":["82302646 82402836 82272432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bacterial infection is a major threat to joint surgery and can lead to amputation or death. However, advanced tools for early, rapid, and accurate identification of joint\u2010infecting bacterial species remain limited. Here, we report a universal strategy for fabricating ultrabright near\u2010infrared (NIR) AIEgen fluorescent probes (PPANPs) that enable lateral flow assay (LFA)\u2010based rapid bacterial identification in joint fluid before surgery, as well as in situ imaging diagnosis and photothermal antibacterial intervention in the joint cavity. Structurally, PPANPs display a core\u2013shell\u2013shell architecture, in which aggregated NIR AIEgens form the fluorescent core, NIR lead sulfide (OA\u2010PbS) forms the inner shell, and poly(maleic anhydride\u2010alt\u20101\u2010octadecene) (PMAO) forms the outer shell. This spatially confined design combines physical confinement, ligand\u2010mediated molecular organization, and cooperative luminescence within the PbS\u2013AIE hybrid nanoassembly, promoting compact and ordered AIE packing and thereby enhancing NIR fluorescence intensity, quantum yield, and photothermal performance compared with conventional embedding methods. s a diagnostic platform, PPANP\u2010labeled LFA achieves 100% sensitivity for Staphylococcus aureus (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) identification within 10\u00a0min, outperforming standard plate culture (&gt;96\u00a0h). Moreover, PPANPs enable rapid in situ imaging of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    infection in mouse joints within 30\u00a0min and exhibit potent photothermal antibacterial activity in vitro under low\u2010power\u2010density laser irradiation.\n                  <\/jats:p>","DOI":"10.1002\/advs.78156","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:22:21Z","timestamp":1791350541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatially Confined\/Ligand\u2010Directed Ultrabright NIR\u2010AIE Nanoprobe for In Vitro Rapid Detection and In Situ Imaging of Bacterial Septic Arthritis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-4493","authenticated-orcid":false,"given":"Yujian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery The First Affiliated Hospital 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