{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:41Z","timestamp":1791352241426,"version":"4.3.1"},"reference-count":87,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Electrochemiluminescence (ECL) underpins ultrasensitive clinical assays, yet current platforms are largely dominated by antibody\u2012antigen immunoassay formats, which are intrinsically difficult to translate to small\u2010molecule detection. The limited size of small molecules, together with the lack of multiple accessible epitopes, restricts the applicability of conventional sandwich architectures and calls for alternative recognition strategies capable of directly coupling molecular binding to ECL signal generation. Herein, we introduce a supramolecular ECL approach in which a recognition unit (cucurbit[7]uril) is covalently integrated with an ECL\u2010active luminophore (tris(2,2\u2032\u2010bipyridyl)ruthenium(II), [Ru(bpy)\n                    <jats:sub>3<\/jats:sub>\n                    ]\n                    <jats:sup>2+<\/jats:sup>\n                    ) to create a compact, self\u2010contained, and recognition\u2010responsive emitter. This architecture provokes an intramolecular ECL generation pathway by preorganizing the protonated coreactant tri\u2010\n                    <jats:italic>n<\/jats:italic>\n                    \u2010propylamine (TPrA) inside the host, leading to a 162% increase in ECL intensity compared to the benchmark [Ru(bpy)\n                    <jats:sub>3<\/jats:sub>\n                    ]\n                    <jats:sup>2+<\/jats:sup>\n                    \/TPrA system, and modulating [Ru(bpy)\n                    <jats:sub>3<\/jats:sub>\n                    ]\n                    <jats:sup>2+<\/jats:sup>\n                    excited\u2010state properties through dynamic intramolecular host\u2013guest interactions. Competitive binding of small molecules, including clinically relevant metabolites and hormones, perturbs this intramolecular equilibrium and reprograms both ECL mechanism and enhancement, enabling highly sensitive yet antibody\u2010free detection down to the nanomolar range in buffered media. Hence, our results establish a general supramolecular design principle for the first self\u2010contained, recognition\u2010responsive ECL emitter, opening avenues toward modular and host\u2012guest engineered platforms for chemically programmed ECL transduction.\n                  <\/jats:p>","DOI":"10.1002\/advs.78181","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:09:36Z","timestamp":1791349776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Engineered Supramolecular Pathway for Enhanced Electrochemiluminescence"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3917-7278","authenticated-orcid":false,"given":"Maria Vittoria","family":"Balli","sequence":"first","affiliation":[{"name":"Department of Chemistry \u201cGiacomo Ciamician\u201d University of Bologna  Bologna Italy"},{"name":"National Interuniversity Consortium of Materials Science and Technology (INSTM) University of Bologna Research Unit (UdR Bologna)  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6441-5429","authenticated-orcid":false,"given":"Madhurima","family":"Jana","sequence":"additional","affiliation":[{"name":"Department of Chemistry \u201cGiacomo Ciamician\u201d University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Capolungo","sequence":"additional","affiliation":[{"name":"Department of Chemistry \u201cGiacomo Ciamician\u201d University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-1485","authenticated-orcid":false,"given":"Patrick","family":"Gruhs","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology (INT) Karlsruhe Institute of Technology (KIT)  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-5998","authenticated-orcid":false,"given":"Pierre","family":"Picchetti","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology (INT) Karlsruhe Institute of Technology (KIT)  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-2072","authenticated-orcid":false,"given":"Giovanni","family":"Valenti","sequence":"additional","affiliation":[{"name":"Department of Chemistry \u201cGiacomo Ciamician\u201d University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-6529","authenticated-orcid":false,"given":"Frank","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology (INT) Karlsruhe Institute of Technology (KIT)  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1630-8291","authenticated-orcid":false,"given":"Luca","family":"Prodi","sequence":"additional","affiliation":[{"name":"Department of Chemistry \u201cGiacomo Ciamician\u201d University of Bologna  Bologna Italy"},{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1038\/s41467-025-60265-8","article-title":"Spatially Blocked Split CRISPR\u2010Cas12a System for Ultra\u2010Sensitive and Versatile Small Molecule Activation and Detection","volume":"16","author":"Hu H.","year":"2025","journal-title":"Nature Communications"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123953","article-title":"In Situ 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