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Single\u2010cell RNA sequencing and tissue\u2010specific fluorescent reporter mice (\n                    <jats:italic>\n                      Prg4\n                      <jats:sup>GFPCreERt2<\/jats:sup>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>Lyz2\u2010iCre;tdTomato<\/jats:italic>\n                    ) reveal that GLUT1 marks a hyperinflammatory synovial state coupled to impaired selenoprotein\u2010dependent redox homeostasis. Accordingly, mannose\u2010modified selenium nanoparticles (M\u2010SeNPs) are developed as an intra\u2010articular nanotherapeutic targeting hypermetabolic synovial niches while restoring redox balance and reprogramming dysregulated metabolism. M\u2010SeNPs are successfully synthesized and characterized, demonstrating preferential uptake by the GLUT1\n                    <jats:sup>high<\/jats:sup>\n                    cells. Proteomic analysis indicates that the robust anti\u2010inflammatory activity of M\u2010SeNPs stems from coordinated metabolic reprogramming and reconstitution of the endogenous antioxidant system, driven by alterations in glycolytic protein and multiple selenoproteins. In vivo, studies demonstrate that, M\u2010SeNPs selectively accumulate in inflamed synovial tissues, effectively alleviating OA\u2010associated pain and restoring joint function. Histological and immunofluorescence analyses further demonstrate pronounced chondroprotection efficacy of M\u2010SeNPs in OA mouse models, which is redominantly mediated by metabolic rewiring and redox homeostasis restoration in the GLUT1\n                    <jats:sup>high<\/jats:sup>\n                    synoviocytes. Collectively, our results establish M\u2010SeNPs as a compelling candidate for OA treatment via selective modulation of synovial metabolic pathway.\n                  <\/jats:p>","DOI":"10.1002\/advs.78188","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:51:26Z","timestamp":1791352286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic\u2010Redox Remodeling of Inflammatory Synovium by Mannose\u2010Modified Selenium Nanoparticles for Osteoarthritis Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6313-1970","authenticated-orcid":false,"given":"Yu\u2010Qing","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery The First Affiliated Hospital of Jinan University Key Laboratory of Regenerative Medicine of Ministry of Education Jinan University  Guangzhou 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